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An in vitro Shwartzman reaction‐like response is augmented age‐dependently in human peripheral blood mononuclear cells
It is demonstrated that human peripheral blood mononuclear cells (PBMC) from healthy adults/elderly, cultured with IL‐12 for 24 h and with LPS for an additional 24 h, produced a much larger amount of TNF (which increased age‐dependently) than did PBMC without IL‐ 12 priming.
A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56bright NKcells
- Tomohiro Kubo, Kengo Sato, S. Nonoyama
- Medicine, BiologyScandinavian journal of infectious diseases
- 1 January 2006
We describe a 15-month-old girl with acute necrotizing encephalopathy (ANE) associated with HHV-6. Inflammatory cytokines were elevated in the CSF and serum and the number of CD56bright NK cells was…
Critical role of the liver CD8+ CD122+ T cells in the generalized Shwartzman reaction of mice
Although the depletion of NK/NK T’cells did not decrease the IFN‐γ or TNF‐α production in the Shwartzman reaction of the middle‐aged mice, an additional depletion of CD8+CD122+ T cells did decrease such production and also improved mouse survival.
Effects of tri-, di- and monobutyltin on synaptic parameters of the cholinergic system in the cerebral cortex of mice.
It is concluded that tributyltin metabolites inhibit various parameters of cholinergic activity with a potency ranking of tributalgtin > dibutyltin > monobutylt in.
PRAC2: A new gene expressed in human prostate and prostate cancer
This report has identified PRAC2, another gene with a similar expression pattern that is located adjacent to the original PRAC gene on chromosome 17q21.3.
IL‐15‐induced CD8+CD122+ T cells increase antibacterial and anti‐tumor immune responses: implications for immune function in aged mice
- A. Motegi, M. Kinoshita, A. Inatsu, Y. Habu, D. Saitoh, S. Seki
- Biology, MedicineJournal of leukocyte biology
- 1 October 2008
The results further support that CD8+CD122+ T cells, which are increased physiologically or therapeutically by IL‐15, are involved in antibacterial immunity, anti‐tumor immunity, and the GSR.
A non‐obese boy with Prader‐Willi syndrome shows cardiopulmonary impairment due to severe kyphoscoliosis
- T. Tokutomi, Ayako Chida, S. Nonoyama
- MedicineAmerican journal of medical genetics. Part A
- 15 September 2006
This report describes a non-obese boy with PWS who also presented with cardiopulmonary impairment due to severe kyphoscoliosis and underwent combined anterior fusion with posterior corrective fusion surgery using spinal instrumentation at age 11 years.
Primary Amenorrhea in an 18-Year Old Patient with Premenarcheal Onset Anorexia Nervosa after Reaching an Appropriate Body Weight
It is suggested that the hypothalamopituitary-gonadal axis rather than the GH-IGF-I axis could be severely damaged by an inappropriate weight loss for several years during early adolescence in association with AN pathophysiology.
199 Prevalence of the anti-GAD antibody in the autoimmune thyroid disease patients