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Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.
TLDR
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes and could lead to the design of new therapeutic treatment modalities for conditions such as Alzeimer's and Creutzfeldt-Jakob disease. Expand
Pathways linkingl-phenylalanine and 2-phenylethylamine withp-tyramine in rabbit brain
TLDR
Evidence is provided for a new biochemical pathway in brain for p-tyramine biosynthesis, with L-phenylalanine (bypassing the formation of L-tyrosine) or 2-phenylethylamine as precursors, with the significance and implications of these metabolic routes discussed. Expand
A review of orthostatic blood pressure regulation and its association with mood and cognition
TLDR
This paper will review literature that examines the psychological and neuropsychological correlates of orthostatic blood pressure regulation and identify possible causes and consequences of subclinical and clinical OH. Expand
Matrix metalloproteinase profile in patients with Creuztfeldt-Jakob disease.
Preliminary findings suggest that abnormalities in matrix metalloproteinase (MMP) activity may be found in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob disease (CJD). In thisExpand
Brain 2-phenylethylamine as a major mediator for the central actions of amphetamine and methylphenidate.
TLDR
The ability of PEA depleters to selectively block the stimulant effects of D-amphetamine, together with the close structural and pharmacological similarities between amphetamine and PEA, and marked influence of amphetamine administration upon PEA brain levels, synthesis and metabolism, suggest to us that many of the central actions of Amphetamine may be mediated by endogenous PEA. Expand
A review of the etiology, associated comorbidities, and treatment of orthostatic hypotension.
TLDR
A better understanding of the underlying causes responsible for the etiology of OH could lead to a rational design of novel effective therapeutic regimens for the treatment of this condition and associated comorbidities. Expand
ENHANCEMENT OF NATURAL KILLER CELL ACTIVITY IN HIV‐1‐INFECTED SUBJECTS BY A MIXTURE OF THE CALCIUM IONOPHORE A23187 AND THE PHORBOL ESTER TPA: LACK OF RESPONSE TO A SIMILAR CHALLENGE WITH
TLDR
The results indicate that control or patient baseline NKC activity, and the response of this cellular immune function to a challenge are indicated, and a similar challenge for samples from the HIV-1-positive subjects resulted in most cases in an enhanced N KC activity. Expand
Posttraumatic Stress Disorder: Etiology, Phenomenology, and Treatment
Etiology of Posttraumatic Stress Disorder. Vulnerability to posttraumatic stress disorder. Dissociative mechanisms in posttraumatic stress disorder. The resilience hypothesis and posttraumatic stressExpand
Etiology and Risk Factors for Developing Orthostatic Hypotension
TLDR
Factors should be considered when diagnosing OH and when prescribing remedies for both patients with OH and those without OH; medication's contributions to the severity and/or risk of developing OH could limit their use. Expand
Studies in the mechanism of phenylethylamine uptake by rabbit erythrocytes.
TLDR
Preliminary results indicate that amphetamine PEA share a similar mechanism for their uptake by rabbit erythrocytes and the Na+-K+ gradient as the driving force responsible for operation of the carrier mechanism. Expand
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