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Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
Resistance to several prevalent infectious diseases requires both cellular and humoral immune responses. T cell immunity is initiated by mature dendritic cells (DCs) in lymphoid organs, whereasExpand
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Host Cell Invasion by TRYPANOSOMA cRUZI Is Potentiated by Activation of Bradykinin B2 Receptors
The parasitic protozoan Trypanosoma cruzi employs multiple molecular strategies to invade a broad range of nonphagocytic cells. Here we demonstrate that the invasion of human primary umbilical veinExpand
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Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages
Malaria sporozoites induce swift activation of antigen-specific CD8+ T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigenExpand
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IL‐4 induces a wide‐spectrum intracellular signaling cascade in CD8+ T cells
IL‐4 has distinct effects on the differentiation and functional properties of CD8+ T cells. In vivo studies have shown that it is critical for the development of protective memory responses againstExpand
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Immune Escape Strategies of Malaria Parasites
Malaria is one of the most life-threatening infectious diseases worldwide. Immunity to malaria is slow and short-lived despite the repeated parasite exposure in endemic areas. Malaria parasites haveExpand
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Early Self-Regulatory Mechanisms Control the Magnitude of CD8+ T Cell Responses Against Liver Stages of Murine Malaria1
Following immunization with Plasmodium yoelii sporozoites, the CD8+ T cell population specific for the SYVPSAEQI epitope expressed in sporozoite and liver stages of this malaria parasite revealed theExpand
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A role for extracellular amastigotes in the immunopathology of Chagas disease.
In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remainExpand
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Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas ofExpand
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The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
Leishmania is a genus of protozoan parasites that give rise to a range of diseases called Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries. Leishmania donovaniExpand
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Leishmania Antigens Are Presented to CD8+ T Cells by a Transporter Associated with Antigen Processing-Independent Pathway In Vitro and In Vivo
CD8+ T cells are generated in response to Leishmania major (Lm) or Toxoplasma gondii parasitic infections, indicating that exogenously delivered Ag can be processed for presentation by MHC class IExpand
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