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[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
- Y. Okuda, F. Sagami, P. Tirone, A. Morisetti, S. Bussi, R. Masters
- MedicineThe Journal of toxicological sciences
- 15 November 1999
The No Observed Adverse Effect Level (NOAEL) for general toxicity of dams and embryo-fetal development was 0.3 mmol/kg/day, and that of mated NZW female rabbits treated with Gadobenate dimeglumine (E7155) caused initial, notable loss of body weight and reduction in food consumption.
Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium.
- A. Morisetti, S. Bussi, P. Tirone, C. de Haën
- MedicineJournal of computer assisted tomography
- 1 November 1999
Based on the wide margins of safety demonstrated in different species, particularly in primates, gadobenate dimeglumine can be considered as safe in the range of clinical doses recommended for magnetic resonance imaging.
The factor time in acute intravenous toxicity studies of contrast media.
Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo…
- C. Parolini, M. Marchesi, +12 authors G. Chiesa
- MedicineJournal of the American College of Cardiology
- 18 March 2008
These results confirm the efficacy of ETC-216 for atherosclerosis treatment and provide guidance for dose selection and frequency to obtain a significant reduction of plaque volume.
Gadocoletic Acid Trisodium Salt (B22956/1): A New Blood Pool Magnetic Resonance Contrast Agent With Application in Coronary Angiography
On the basis of the pharmacokinetic profile and imaging characteristics, gadocoletic acid trisodium salt shows promise as a MR contrast agent for coronary angiography.
Effects of iodinated contrast media on endothelium: An in vitro study.
- S. Ramponi, A. Grotti, A. Morisetti, S. Vultaggio, V. Lorusso
- MedicineToxicology in vitro : an international journal…
- 1 March 2007
Ionic CM show to strongly affect endothelial cells viability under all tested conditions, while non-ionic CM show effects only after prolonged exposure at 50 and 100mg/mL, which represent instant concentrations lasting just minutes after intravascular injection of CM.
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
- F. Luzzani, A. Morisetti, S. Bussi, P. Tirone, C. de Haën
- MedicineInvestigative radiology
- 1 June 1996
Neurotoxicity of monomer or dimer contrast media depends more on chemical structure characteristics other than hydrophilicity than on the physicochemical characteristics of their solutions.
Iopiperidol: nonionic iodinated contrast medium with promising anticoagulant and antiplatelet properties.
In vitro, iopiperidol showed anticoagulant properties similar or superior to those of the ionic ioxaglate, and the in vivo effect is similar to that of reference nonionic contrast media.
Toxicological safety assessment of iomeprol, a new X-ray contrast agent.
Intravenous daily dosing for 4 weeks showed that iomeprol was well tolerated at doses as high as the maximum dose anticipated for clinical use and tissue tolerability was completely superimposable on those of reference CM such as iopamidol and iohexol.
Conjugates of gadolinium complexes to bile acids as hepatocyte-directed contrast agents for magnetic resonance imaging.
- P. Anelli, L. Lattuada, +5 authors F. Uggeri
- Chemistry, MedicineJournal of medicinal chemistry
- 5 June 2004
Among the most promising terms, a second generation conjugate in which the Gd(III) complex is linked to cholic acid through the 3alpha hydroxy group seems to enter hepatocytes using the Na(+)/taurocholate transporter.