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Proteomic Investigation of the Effect of Salicylic Acid on Arabidopsis Seed Germination and Establishment of Early Defense Mechanisms1[W][OA]
TLDR
This molecule enhanced the reinduction of the late maturation program during early stages of germination, thereby allowing the germinating seeds to reinforce their capacity to mount adaptive responses in environmental water stress and improve seed vigor.
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Gating pore currents and the resting state of Nav1.4 voltage sensor domains
TLDR
A structural model rationalizes the activation sequence of the different VSDs of the Nav1.4 channel and shows that the hydrophobic septa that isolate the intracellular and the extracellular media within the DI, DII, and DIII V SDs are ∼2 Å long, similar to those of Kv channels.
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Biophysics, pathophysiology, and pharmacology of ion channel gating pores
TLDR
This focus on the VSD motif opens up a new area of research centered on developing molecules to treat a number of cell excitability disorders such as epilepsy, cardiac arrhythmias, and pain.
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Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy
Nav1.5 channels bearing voltage-sensor domain mutations associated with atypical cardiac arrhythmias and dilated cardiomyopathy generate gating pore currents.
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Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4
Insect DSC1 channels have sequences that are intermediate between voltage-gated Na+ and Ca2+ channels but have hitherto been classified as the former. Gosselin-Badaroudine et al. clone and…
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Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations
TLDR
It is likely that the clinical phenotypes observed in these two BrS patients were related to a surface expression defect caused by ER retention, which could be partially reversed by incubating transfected cells at 25°C and by treating them with mexiletine or thapsigargin, two drugs that target ER resident proteins.
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Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy
TLDR
An increasing number of ion channelopathies, including periodic paralysis, dilated cardiomyopathy associated with cardiac arrhythmias, and peripheral nerve hyperexcitability (PNH), have been linked to the appearance of a new pathological mechanism involving the creation of an alternative permeation pathway through the normally non-conductive VSD of VGIC.
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Gating Pore Currents in Sodium Channels.
TLDR
Simulations have provided valuable insight into the nature of S4 translocation and the physical basis for the effects of mutations that promote permeation of protons or cations through the gating pore.
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Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides
TLDR
The functional expression and the molecular, biophysical, and pharmacological characterization of the western honeybee’s sodium channel are reported and could be used to assess the risks that current and next generation pesticides pose to honeybee populations.
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Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes
TLDR
The molecular remodeling is for the first time revealed using patient-specific hiPSC-derived cardiomyocytes which may explain the CPVT proband’s resistance.
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