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- Publications
- Influence
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
- J. Wang, P. Sakariassen, +10 authors P. Ø. Enger
- Biology, Medicine
- International journal of cancer
- 15 February 2008
CD133 is a cell surface marker expressed on progenitors of haematopoietic and endothelial cell lineages. Moreover, several studies have identified CD133 as a marker of brain tumor‐initiating cells.… Expand
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
- J. Flannick, G. Thorleifsson, +77 authors D. Altshuler
- Biology, Medicine
- Nature Genetics
- 1 April 2014
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or… Expand
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
- Anja Ragvin, E. Moro, +15 authors T. Becker
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 22 December 2009
Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium (LD) blocks encompassing HHEX-IDE and introns of CDKAL1 and FTO [Sladek… Expand
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas
- H. Immervoll, D. Hoem, P. Sakariassen, O. Steffensen, A. Molven
- Biology, Medicine
- BMC Cancer
- 8 February 2008
BackgroundIt has been suggested that a small population of cells with unique self-renewal properties and malignant potential exists in solid tumors. Such "cancer stem cells" have been isolated by… Expand
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
- J. Sagen, H. Raeder, +12 authors P. Njølstad
- Medicine
- Diabetes
- 1 October 2004
Permanent neonatal diabetes (PND) can be caused by mutations in the transcription factors insulin promoter factor (IPF)-1, eukaryotic translation initiation factor-2alpha kinase 3 (EIF2AK3), and… Expand
Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction
- H. Ræder, S. Johansson, +13 authors P. Njølstad
- Biology, Medicine
- Nature Genetics
- 2006
Dysfunction of the exocrine pancreas is observed in diabetes, but links between concurrent exocrine and endocrine pancreatic disease and contributing genetic factors are poorly characterized. We… Expand
Genome-wide association study identifies three new melanoma susceptibility loci
- J. Barrett, M. Iles, +72 authors D. Bishop
- Biology, Medicine
- Nature Genetics
- 9 October 2011
We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control… Expand
FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life
- J. Hertel, S. Johansson, +13 authors P. Njølstad
- Medicine
- Diabetes
- 23 April 2011
OBJECTIVE FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO… Expand
Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation.
Inappropriately elevated insulin secretion is the hallmark of persistent hyperinsulinemic hypoglycemia of infancy (PHHI), also denoted congenital hyperinsulinism. Causal mutations have been uncovered… Expand
A variant in FTO shows association with melanoma risk not due to BMI
- M. Iles, M. Law, +87 authors J. Barrett
- Biology, Medicine
- Nature Genetics
- 3 March 2013
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL… Expand