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Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils.
TLDR
This review will consider the ability of selective analogues (ligands able to discriminate between different biological responses) to activate a single spectrum of signal transduction pathways capable of producing a unique set of cellular responses, hypothesising that a distinctive imprint of signal protein activation may exist.
Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies
TLDR
Overall, Goji leaves are a rich source of bioactive compounds with functional properties that need further risk/benefit evaluation when used in foods or health-promoting formulations.
In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz - An endemic folk medicinal plant
TLDR
The present study attempts for the first time to assess the possible enzyme inhibitory potential, antioxidant activity, and phytochemical profile of the ethyl acetate, methanol, and water extracts of C. saligna and shows that apigenin binds to the enzymatic pocket of α-glucosidase and is stabilised by a network of hydrogen bonds and pi-pi stacking.
In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from nature.
TLDR
The three halophytes studies could be considered as potential sources of biologically-active compounds for novel phytopharmaceuticals development.
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential
TLDR
Results showed that the regular administration of C. spinosa leaf or buds normalized all the biochemical parameters and reversed the liver/kidney injury with variable degrees of organ protection.
Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications.
TLDR
Cotoneaster integerrimus has a great potential as a health promoter for developing novel functional food ingredients and pharmaceutical preparations and for biological and chemical profile evaluation.
Multidirectional investigations on different parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensities.
TLDR
The results suggest that the different plant parts of A. scorodoprasum possessed different biological activities and might be used as a medicinal food plants for specific therapeutic applications.
Prodrug Approach for Increasing Cellular Glutathione Levels
TLDR
Different strategies for increasing GSH levels by supplying reversible bioconjugates able to cross the cellular membrane more easily than GSH and to provide a source of thiols for GSH synthesis are discussed.
Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.).
TLDR
The results strongly advocate that future formulation of C. spinosa as active ingredient should also take into account the geographical origins and extraction techniques.
Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems
TLDR
The beneficial properties of medicinal-chemistry- and technology-based approaches used in order to replenish intracellular GSH levels, which are reduced in neurodegenerative diseases, are discussed.
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