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Relative responses of aortic body and carotid body chemoreceptors to carboxyhemoglobinemia.
It is hypothesized that the aortic bodies have a much lower perfusion relative to their O2 utilization compared to the carotid bodies, and are able to act as a sensitive monitor of O2 delivery and to generate a circulatory chemoreflex for O2 homeostasis. Expand
Carbonic anhydrase and chemoreception in the cat carotid body.
The results indicated that CA in the glomus cells played a crucial role primarily in the speed and magnitude of the initial response to CO2 stimulus and indirectly influenced O2 chemoreception. Expand
The primary oxygen sensor of the cat carotid body is cytochrome a 3 of the mitochondrial respiratory chain
Carbon monoxide was shown to be competitive with O2 in oxygen sensing by perfused carotid bodies isolated from cats, afferent electrical activity increasing with either decreasing O2 or increasingExpand
Nitric oxide-related inhibition of carotid chemosensory nerve activity in the cat.
Evidence is provided in favor of an inhibitory role of endogenous NO in the carotid body, and exogenous application of NO confirms the inhibitory effect. Expand
Carotid body chemosensory function in prolonged normobaric hyperoxia in the cat.
It was found that chronic hyperoxia severely blunted or eliminated the O2-sensitive response of the carotid chemoreceptors while augmenting the hypercapnic response. Expand
Time-dependent effect of hypoxia on carotid body chemosensory function.
It is concluded that isocapnic hypoxia may not elicit a sufficient cellular response within 2-3 h in the cat carotid body to sensitize the O2 responsive mechanism, butHypoxia of longer duration will sensitize such a mechanism, thereby augmenting the chemosensory activity. Expand
Comparison of aortic and carotid chemoreceptor responses to hypercapnia and hypoxia.
It is suggested that the low CO2 response of aortic body chemoreceptors is responsible for their blunted hypoxic response. Expand
Peripheral and central dopamine receptors in respiratory control.
The hypothesis that both peripheral and central dopaminergic mechanisms play a significant modulatory role in chemoreflex respiratory control is supported. Expand
Dynamics of carotid body responses in vitro in the presence of CO2-HCO3-: role of carbonic anhydrase.
The role of carbonic anhydrase (CNA) in the dynamics of carotid body (CB) function was tested by studying the effects of the membrane-permeable CNA inhibitor methazolamide on the chemosensory responses of the cat CB in vitro with cell-free and modified Tyrode solution. Expand
Reciprocal photolabile O2 consumption and chemoreceptor excitation by carbon monoxide in the cat carotid body: evidence for cytochrome a3 as the primary O2 sensor
There were no significant differences in baseline neural discharge or in the maximum neural discharge after flow interruption, and little effect on O2 metabolism during perfusion with high CO in the light, according to a metabolic hypothesis of O2 chemoreception. Expand