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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
- Mats I. Ekstrand, M. Terzioğlu, N. Larsson
- BiologyProceedings of the National Academy of Sciences
- 23 January 2007
It is demonstrated that respiratory chain dysfunction in DA neurons may be of pathophysiological importance in PD and reduced mtDNA expression and respiratory chain deficiency in midbrain DA neurons leads to a parkinsonism phenotype.
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
- B. Ickes, T. Pham, L. Sanders, D. Albeck, A. Mohammed, A. Granholm
- Biology, PsychologyExperimental Neurology
- 1 July 2000
Findings demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and morphological alterations that have been found to occur with a shifting environmental stimulus.
Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year
Association between mid-life marital status and cognitive function in later life: population based cohort study
Living in a relationship with a partner in mid-life might imply cognitive and social challenges that have a protective effect against cognitive impairment later in life, consistent with the brain reserve hypothesis.
Psychological stress and environmental adaptation in enriched vs. impoverished housed rats
Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats
Environmental influences on brain neurotrophins in rats
Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance
- N. El-bakri, A. Islam, A. Adem
- Biology, PsychologyJournal of cellular and molecular medicine
- 1 October 2004
The changes of NMDA receptors in the hippocampus support the concept that estrogen‐enhancing effect on spatial reference memory could be through the enhancing ofNMDA function.
Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor
Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum
The results suggest that the hyperactivity to novelty and psychostimulants as well as other behavioral changes induced by social isolation do not parallel changes in the in vivo function or binding of D2 receptors in dorsal/ventral striatum.