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The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
The factors contributing to selective motoneuron loss in amyotrophic lateral sclerosis (ALS) remain undefined. To investigate whether calcium‐binding proteins contribute to selective motoneuronExpand
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Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.
Calbindin-D28K and/or parvalbumin appear to influence the selective vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS). Their immunoreactivity is undetectable in motoneurons readilyExpand
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Parvalbumin overexpression alters immune‐mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis
Intracellular calcium is increased in vulnerable spinal motoneurons in immune‐mediated as well as transgenic models of amyotrophic lateral sclerosis (ALS). To determine whether intracellular calciumExpand
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Proteins, lipids, lipoproteins and some enzyme characterizations of the venom extract from the centipede Scolopendra morsitans.
Some components of Scolopendra morsitans venom extract were characterized using disc gel electrophoresis and thin layer chromatography. Its protein component was separated into 13 anodal bands and aExpand
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Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures.
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) raise difficult therapeutic problems despite the emergence of targeted therapies. Somatostatin analogs (SSA) remain pivotal therapeutic drugs.Expand
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Apoptotic Cell Death of a Hybrid Motoneuron Cell Line Induced by Immunoglobulins from Patients with Amyotrophic Lateral Sclerosis
Abstract: Apoptotic cell death has recently been implicated in diseases involving nonproliferating, terminally differentiated cells such as neurons. Previous experiments have documented thatExpand
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Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces.
Addition of an aqueous extract of Hibiscus sabdariffa calyces (2.5 ml/bath approximately 125 mg of starting crude material) inhibited the tone of various isolated muscle preparations (rabbit aorticExpand
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Hepatitis E virus infection in work horses in Egypt.
Hepatitis E virus (HEV) is an important cause of hepatitis among young Egyptian adults with high seroprevalence rates seen in both rural areas of the Nile Delta and in suburban Cairo. Because naturalExpand
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Effects of an extract from the centipede Scolopendra moristans on intestine, uterus and heart contractions and on blood glucose and liver and muscle glycogen levels.
Abstract scolopendra extract caused initial inhibition of rabbit intestine followed by a marked excitation and finally a prolonged phase of inhibition. This effect was abolished by atropine andExpand
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Somatostatin receptor sst2 gene transfer in human prolactinomas in vitro: Impact on sensitivity to dopamine, somatostatin and dopastatin, in the control of prolactin secretion
OBJECTIVE As prolactinomas fail to respond to dopamine agonist (DA) in 10-20% of cases, we hypothesized that somatostatin subtype 2 receptor (sst2) overexpression in DA-resistant prolactinomas mayExpand
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