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Single-cell reconstruction of the early maternal–fetal interface in humans
A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an
Immunology of placentation in eutherian mammals
The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft, but a more recent approach focuses on the unique, local uterine immune response to the implanting placenta.
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.
It is demonstrated that trophoblast expresses both paternally and maternally inherited HLA-C surface proteins and that maternal KIR AA frequencies are increased in affected pregnancies only when the fetus has more group 2 Hla-C genes than the mother, raising the possibility that there is a deleterious allogeneic effect stemming from paternal C2.
Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
It is suggested that the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
These data strongly implicate high HLA-C expression levels in more effective control of HIV-1, potentially through better antigen presentation to cytotoxic T lymphocytes or recognition and killing of infected cells by natural killer cells.
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically-defined medium
These organoids expand long-term, are genetically stable and differentiate following treatment with reproductive hormones, and provide a foundation to study common diseases, such as endometriosis and endometrial cancer, as well as the physiology of early gestation.
Influence of HLA-C Expression Level on HIV Control
It is demonstrated that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4+ T cell counts in African and European Americans.
Unique Receptor Repertoire in Mouse Uterine NK cells1
By multiparametric analysis, it is shown that the phenotype of uNK cells is unique and unprecedented in terms of adhesion, activation, and MHC binding potential, suggesting that a selection process shapes the receptor repertoire of mouse u NK cells.