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Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and β-adrenoceptor binding in the rat
- J. Harro, R. Pähkla, A. Modiri, M. Harro, A. Kask, L. Oreland
- Biology, MedicineJournal of Neural Transmission
The results suggest that the increase inimmobility time in the forced swimming test is associated with presynaptic changes in noradrenaline availability, whereas the decrease in immobility observed after more complete denervation is associatedwith postsynaptic receptor supersensitivity.
Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment
Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats.
Lesioning of locus coeruleus projections by DSP-4 neurotoxin treatment: effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in rats.
- J. Harro, A. Meriküla, M. Lepiku, A. Modiri, A. Rinken, L. Oreland
- Biology, PsychologyPharmacology & toxicology
- 1 May 2000
The data suggest that supersensitivity of D2 receptors develops after locus coeruleus denervation, but that the enhanced efficacy of amphetamine in DSP-4-treated rats is masked by neophobia.
Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.
Ethylmorphine O‐deethylation cosegregates with the debrisoquin genetic metabolic polymorphism
- A. Rane, A. Modiri, E. Gerdin
- Chemistry, BiologyClinical pharmacology and therapeutics
- 1 September 1992
The data suggest that ethylmorphine is O‐ deethylated by the cytochrome P4502D6 isozyme inasmuch as both the fractional metabolic clearance by O‐dealkylation and the MRO were found to cosegregate with the phenotype for the O‐demethylation of dextromethorphan in the authors' group of subjects.
Selectivity of Oxymetazoline for Urethral Pressure vs Blood Pressure in the Anaesthetized Female Rabbit
- A. Modiri, M. Gunnel Fredrickson, P. Gillberg, P. Alberts
- Medicine, BiologyScandinavian journal of urology and nephrology
- 1 January 2000
The results suggest that in the female rabbit in vivo activation of alpha1-adrenoceptors increased the urethral pressure and it would seem possible to develop urethra-selective drugs for treatment of stress incontinence with few or no cardiovascular side-effects.
Characterization of a new muscarinic receptor antagonist PNU-171990 in guinea pig, cat and human smooth muscle.
Pharmacological characterisation of the enantiomers of BM-5, a muscarinic partial agonist with opposed enantioselectivity between affinity and efficacy.
- S. Sundquist, A. Modiri, B. Nilsson, U. Hacksell, P. Gillberg, L. Nilvebrant
- Biology, ChemistryPharmacology & toxicology
- 28 June 2008
It can be concluded that the effects of racemic BM-5 are mediated by the (R)-enantiomer, which was the more potent enantiomer but had a lower maximal agonist effect giving an opposed enantioselectivity for affinity and efficacy.