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ISCEV standard for clinical visual evoked potentials: (2016 update)
TLDR
This document updates the ISCEV standard for clinical VEP testing and supersedes the 2009 standard, acknowledging that pattern stimuli can be produced using a variety of technologies with an emphasis on the need for manufacturers to ensure that there is no luminance change during pattern reversal or pattern onset/offset.
Complement factor H polymorphisms in Japanese population with age-related macular degeneration.
TLDR
The frequencies of these haplotypes were significantly different between Japanese and American in both control and case groups and one protective haplotype was identified that decreased the likelihood of AMD.
Dp260 disrupted mice revealed prolonged implicit time of the b-wave in ERG and loss of accumulation of beta-dystroglycan in the outer plexiform layer of the retina.
TLDR
These ERG findings differed from those of DMD and BMD patients, especially with regard to amplitude of the b-wave, but make it clear that Dp260 is required for normal electrophysiology.
Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population
TLDR
It is concluded that dry-type AMD, typical wet- type AMD, and PCV have both common and distinct genetic risks that become apparent when comparing Japanese versus Caucasian populations.
Reactive gliosis of astrocytes and Müller glial cells in retina of POMGnT1-deficient mice
TLDR
The results suggest that altered glycosylation of alpha-DG may be responsible for the reactive gliosis and reticular fibrosis in the retina, and the subsequent developments of retinal dysplasia, abnormal ERGs, and retinal detachment in the mutant mice.
HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration
TLDR
The HTRA1 promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular AMD.
Clinical characteristics of Japanese children with optic neuritis.
TLDR
The percentage of optic neuritis cases that developed multiple sclerosis in children was similar to that for children in Europe and North America, and this percentage was not lower than that in adults in the clinic.
Molecular composition of drusen and possible involvement of anti‐retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis)
TLDR
Monkey drusen both in late and early onset forms of macular degeneration had common components with Drusen in human AMD patients, indicating that chronic inflammation mediated by complement activation might also be involved in the formation of drusan in these affected monkeys.
Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats.
TLDR
Electroporation is an effective method for the direct delivery of genes into RGCs, and that the BDNF gene transferred into R GCs by in vivo electroporation can protect axotomized RGC's against apoptosis are demonstrated.
One-year outcomes with half-dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy.
TLDR
Half-dose PDT is an effective and safe method to treat eyes with chronic CSC with an SRD and the CSC resolved and the BCVA improved significantly after PDT, compared with cases without intense hyperpermeability on ICGA and those with lower BCVA before the PDT.
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