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Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target
TLDR
Results show that Hh signaling is important in the pathogenesis of B-CLL and, hence, may be a potential therapeutic target, and selective down-regulation of GLI1 by antisense oligodeoxynucleotides (GLI1-ASO) results in decreased BCL2 expression and cell survival, suggesting that GLI 1 may regulate BCL 2 and, thereby, modulate cell survival in B- CLL.
Free Radical Scavenging and Antioxidant Activity of Silver Nanoparticles Synthesized from Flower Extract of Rhododendron dauricum
A simple and efficient eco-friendly approach for the biosynthesis of stable, monodisperse silver nanoparticles (AgNPs) using Rhododendron dauricum flower extract is described. Different reaction
Comparative studies of anticancer and antimicrobial potential of bioinspired silver and silver-selenium nanoparticles
TLDR
The results concluded that Syzygium cumini silver nanoparticles were highly active at the minimum concentration of 10 µg/mL against all type of cells and destroy the bacterial and tumour cells in a dose-dependent manner.
Lymph node‐induced immune tolerance in chronic lymphocytic leukaemia: a role for caveolin‐1
TLDR
A novel role for CAV1 in tumour‐induced immunosuppression during the progression of CLL is reported, specifically those involved in actin polymerization.
Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia
TLDR
Results indicate that microenvironment-controlled-CTLA4 expression mediates proliferation/survival of CLL cells by regulating the expression/activation of STAT1, NFATC2, c-Fos,c-Myc, and/or Bcl-2.
Modeling and informatics in designing anti-diabetic agents.
TLDR
A review of the rational approaches reported in designing anti-diabetic agents is presented in this article and can be emulated in many other therapeutic areas.
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