EB/RP gene family encodes tubulin binding proteins
- J. Juwana, P. Henderikx, C. Renner
- BiologyInternational Journal of Cancer
- 12 April 1999
It is shown that RP1 and the other known members of the EB/RP family (EB1 and RP3) also bind directly to tubulin, both in vitro and in vivo.
Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
- P. Schuberth, C. Hagedorn, U. Petrausch
- Biology, MedicineJournal of Translational Medicine
- 12 August 2013
The data support performing a phase I clinical trial in which MPM patients are treated with adoptively transferred FAP-specific re-directed T cells, which showed antigen-specific functionality in vitro and in vivo.
Prospective study on the expression of cancer testis genes and antibody responses in 100 consecutive patients with primary breast cancer
- A. Mischo, B. Kubuschok, M. Pfreundschuh
- Biology, MedicineInternational Journal of Cancer
- 1 February 2006
It is shown that breast carcinomas are among the tumors with the most frequent expression of CT antigens, rendering many patients potential candidates for vaccine trials.
Regulating functional cell fates in CD8 T cells
- P. Shrikant, Rajesh R. Rao, P. Singhal
- BiologyImmunologic research
- 1 March 2010
The focus of the laboratory investigations is to identify the extrinsic factors such as antigen strength, co-stimulatory molecules, cytokines, and small molecule modifiers that regulate intrinsic programs for various effector and/or memory cell fate in antigen specific CD8 T cells.
Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma
- P. Schuberth, G. Jakka, U. Petrausch
- Biology, MedicineGene Therapy
- 28 June 2012
Re-directed effector- and central memory T cells specifically recognized NY-ESO-1157–165/ HLA-A*02:01-positive cells resulting in antigen-specific functionality in vitro and in vivo.
Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma1
- S. Bihr, R. Ohashi, P. Schraml
- 16 January 2019
Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
- C. Razafinjatovo, S. Bihr, P. Schraml
- BiologyBMC Cancer
- 17 August 2016
VHL missense mutations may exert mild, moderate or strong impact on pVHL stability, and are rather appropriate for designing tailor-made treatment strategies for ccRCC.
Recombinant antigen expression on yeast surface (RAYS) for the detection of serological immune responses in cancer patients.
RAYS appears at least equivalent to both ELISA and Western blotting for the monitoring of antibodies against NY-ESO-1 as regards specificity and sensitivity, while antibodies against SSX2 were detected more frequently by RAYS than by ELISA or phage display.
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience.
- P. Samaras, Marcel Blickenstorfer, C. Renner
- MedicineSwiss medical weekly
- 31 May 2011
ASCT is a safe and effective treatment mode in eligible patients with multiple myeloma and achievement of CR after transplantation was the most valuable predictor for improved overall survival.
Hodgkin's lymphoma in remission after first-line therapy: which patients need FDG-PET/CT for follow-up?
- U. Petrausch, P. Samaras, N. Schaefer
- MedicineAnnals of Oncology
- 1 May 2010
Asymptomatic patients without morphological residues and an early stage of disease do not need a routine FDG-PET/CT for follow-up and patients with advanced initial stage do need to receive a routine follow- up beyond 24 months.