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Functional characterization of naturally occurring mutations of the human adrenocorticotropin receptor: poor correlation of phenotype and genotype.
TLDR
It is demonstrated that several MC2-R mutations associated with familial glucocorticoid deficiency result in an impaired maximal cAMP response or loss of sensitivity for cAMP generation compared to the wild-type receptor. Expand
Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: implications for the RAMP hypothesis.
TLDR
The results suggest that CGRP and AM receptors exhibit different patterns of desensitization in SK-N-MC cells: a finding with significant implications for the RAMP hypothesis. Expand
Desensitisation of calcitonin gene-related peptide responsiveness but not adrenomedullin responsiveness in vascular smooth muscle cells.
TLDR
The results indicate that the ADM receptor does not desensitise over this time period in RAVSMCs, in contrast to the CGRP receptor, which is desensITised by pre-exposure to C GRP and other vaso-active agonists. Expand
Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants.
TLDR
Findings provide evidence that endogenous CO may play a role in the control of CRH release; by analogy with NO, CO may represent a major new neuroendocrine modulator. Expand
Evidence for the neuronal origin of immunoreactive interleukin-1β released by rat hypothalamic explants
TLDR
The present evidence suggests that irIL-1 beta released by rat hypothalamic explants following KCl depolarization is neuronal in origin. Expand
Increased production and release of prostaglandin-E2 by human granulosa cells from polycystic ovaries.
TLDR
Blockade by indomethacin and the weak inhibitory effect of the glucocorticoid, dexamethasone, provided pharmacological evidence that PG production by granulosa cells in vitro might depend primarily on constitutive cyclo-oxygenase activity. Expand
Expression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors.
TLDR
Although both pituitary and ectopic ACTH-secreting tumors are at least partially glucocorticoid-resistant, no significant abnormalities in the relative expression of the two main GR subforms were observed in a series of such tumors and mutations of regions critical to normal function of the receptor do not seem to be a frequent event. Expand
The release of immunoreactive interleukin-1 beta from rat hypothalamic explants is modulated by neurotransmitters and corticotropin-releasing hormone.
TLDR
Investigating the effects of classical neurotransmitters and the hypophysiotropic peptide corticotropin-releasing hormone (CRH) on the release of immunoreactive (ir) IL-1 beta from acute rat hypothalamic explants found that basal irIL-1beta secretion is significantly inhibited by acetylcholine and histamine and increased by dopamine, while dexamethasone, IL-4 and IL-10 have no effect. Expand
Evidence that the interleukin-1β-induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors
TLDR
It is suggested that IL-1 beta controls production and release of PGE2 by the rat hypothalamus via both type I and type II receptors, although the latter appear to be involved only in the response to high levels ofIL-1. Expand
Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.
TLDR
It is shown that the same mutants maintain at least two hypothalamic functions, that is, the in vitro short-term PGE2 release from rat hypothalamus and the induction of fever in rabbits, implying that multiple active sites on the IL-1 beta molecule, possibly binding to more than one receptor chain, trigger different signals. Expand
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