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Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis
Summary: The cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective putative 5-HT1A receptor agonist, has been investigated in the rat. Comparisons were made withExpand
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Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam
1 With radioligand binding techniques, MDL 73005 EF (8‐[2‐(2,3‐dihydro‐1,4‐benzodioxin‐2‐yl‐methylamino)ethyl]‐8‐azaspiro[4,5]decane‐7,9‐dione methyl sulphonate) shows high affinity (pIC50 8.6) andExpand
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Biogenic Amine‐Stimulated Cyclic Adenosine‐3′,5′‐Monophosphate Formation in the Rat Carotid Body
Abstract: The subcutaneous injection of isoprenaline, salbutamol, histamine, and adrenaline to rats, which were subsequently killed by microwave irradiation, resulted in a rapid increase in theExpand
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Direct activation of Ca2+ channels by palmitoyl carnitine, a putative endogenous ligand
1 Palmitoyl carnitine, a lipid metabolite which accumulates in cytoplasmic membranes during ischaemia, has been shown to resemble the Ca2+ channel activator, Bay K 8644, in K+‐depolarized smoothExpand
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Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat.
Following intraperitoneal (i.p.) administration BAY K 8644 (0.5-4 mg/kg) induced an increase in blood pressure associated with bradycardia, increased tail-flick latency in response to radiant heat,Expand
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MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors.
In receptor binding assays (+/-)MDL 72832, 8-[4-(1,4-benzodioxan-2-ylmethylamino)butyl]-8-azaspiro++ +[4,5] decane-7,9-dione, was a potent (pIC50 9.1), selective and stereospecific ligand for centralExpand
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Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
A conformational study of four 5-HT1A (serotonin) receptor ligands ((R-(-)-methiothepin, spiperone, (S)-(-)-propranolol, and buspirone) led to the definition of a pharmacophore and aExpand
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Chronic MAO A and MAO B inhibition decreases the 5-HT1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase.
The effect of chronic administration of various monoamine oxidase (MAO) inhibitors on the ability of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to inhibit forskolin-stimulated adenylateExpand
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Biosynthesis of N‐Acetyldopamine and N‐Acetyloctopamine by Schistocerca gregaria Nervous Tissue
Abstract: N‐Acetyltyramine, N‐acetyldopamine and N‐acetyloctopamine were the major products when either L‐[3H]tyrosine or [3H]tyramine were incubated with thoracic ganglia of the desert locust,Expand
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Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase.
(E)-beta-Fluoromethylene-m-tyrosine (MDL 72394) is not per se an inhibitor of monoamine oxidase (MAO) but is a substrate of aromatic L-amino acid decarboxylase (AADC) which liberates the potent MAOExpand
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