Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
- Emilie Layre, H. Lee, D. Moody
- Biology, ChemistryProceedings of the National Academy of Sciences
- 10 February 2014
This strategy identified a previously unknown, Mycobacterium tuberculosis-specific lipid, 1-tuberculosinyladenosine, which is produced by the Rv3378c enzyme, and establishes its role as a tuberculo-prenyl transferase and suggests a revised biosynthetic pathway for the sequential action of Rv 3377c-Rv 3378c.
A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis.
Chiral separation by enantioselective liquid-liquid extraction.
- B. Schuur, Bastiaan J. V. Verkuijl, A. Minnaard, J. D. de Vries, H. J. Heeres, B. Feringa
- ChemistryOrganic and biomolecular chemistry
- 7 January 2011
The principles and advances of resolution through enantioselective liquid-liquid extraction are discussed, and the following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
CD1c tetramers loaded with a phospholipid antigen from M. tuberculosis are recognized by human T cells and are distinguished from normal T cells by the immune system.
CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs.
Chemical immobilisation of humic acid on silica
Converting Escherichia coli into an archaebacterium with a hybrid heterochiral membrane
- A. Caforio, M. Siliakus, J. van der Oost
- Biology, EngineeringProceedings of the National Academy of Sciences
- 19 March 2018
This finding challenges theories that assume that intrinsic instability of mixed membranes led to the “lipid divide” and the subsequent differentiation of bacteria and archaea and paves the way for future membrane engineering of industrial production organisms with improved robustness.
Recent advances in the catalytic asymmetric synthesis of β-amino acids
A review, with 160 references, discussing progress in catalytic asymmetric synthesis of β-amino acids since 2002.
Highly Enantioselective Rhodium-Catalyzed Hydrogenation with Monodentate Ligands
The homogeneous enantioselective hydrogenation of functionalized prochiral olefins is one of the most frequently studied and most efficient transition metal-catalyzed reactions. In the first reports…
Rhodium-catalyzed addition of arylboronic acids to isatins: an entry to diversity in 3-aryl-3-hydroxyoxindoles.
A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite catalyst and allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole building blocks in high yields.