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Distribution and morphology of human cone photoreceptors stained with anti‐blue opsin
Primate cones maximally sensitive to short wavelength light (blue cones) have been previously identified by using indirect methods. We stained 7 wholemounted human retinas obtained from 6 femaleExpand
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Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration.
Many gaps exist in our knowledge of human retinal microglia in health and disease. We address the hypothesis that primary death of rod photoreceptors leads to activation of resident microglia inExpand
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Histopathology of the human retina in retinitis pigmentosa.
The term, 'retinitis pigmentosa', refers to a heterogeneous group of inherited diseases that cause degeneration of rod and cone photoreceptors in the human retina. Loss of photoreceptor cells isExpand
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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNAExpand
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The role of apoptosis in age-related macular degeneration.
OBJECTIVE To investigate apoptosis in human age-related macular degeneration (AMD). METHODS Postmortem retinas with AMD and normal retinas were studied by terminal deoxynucleotidyl transferase dUTPExpand
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Retinal remodeling triggered by photoreceptor degenerations
Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It has long been assumed that the surviving neural retina is largely resistant to this sensoryExpand
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Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis.
OBJECTIVE To determine the extent of preservation in the inner retina in retinitis pigmentosa (RP). METHODS We analyzed sectioned maculae of 21 postmortem eyes with RP and 19 age-matched, normal,Expand
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Recoverin immunoreactivity in mammalian cone bipolar cells.
Human, macaque monkey, and rat retinas were immunostained with a polyclonal antibody preparation against purified recoverin, a 23-kD calcium-binding protein isolated from bovine retina that localizesExpand
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Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2.
PURPOSE To report a novel mouse model of achromatopsia with a cpfl3 mutation found in the ALS/LtJ strain. METHODS The effects of a cpfl3 mutation were documented using fundus photography,Expand
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Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination.
Mutations in CRB1, the human homolog of Drosophila Crumbs, cause autosomal recessive blinding disorders of the retina. Whereas Crumbs is implicated in apical-basal epithelial polarity andExpand
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