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- Publications
- Influence
Distribution and morphology of human cone photoreceptors stained with anti‐blue opsin
- C. Curcio, K. Allen, +4 authors A. Milam
- Biology, Medicine
- The Journal of comparative neurology
- 22 October 1991
Primate cones maximally sensitive to short wavelength light (blue cones) have been previously identified by using indirect methods. We stained 7 wholemounted human retinas obtained from 6 female… Expand
Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration.
- N. Gupta, Kimberly E. Brown, A. Milam
- Biology, Medicine
- Experimental eye research
- 1 April 2003
Many gaps exist in our knowledge of human retinal microglia in health and disease. We address the hypothesis that primary death of rod photoreceptors leads to activation of resident microglia in… Expand
Histopathology of the human retina in retinitis pigmentosa.
The term, 'retinitis pigmentosa', refers to a heterogeneous group of inherited diseases that cause degeneration of rod and cone photoreceptors in the human retina. Loss of photoreceptor cells is… Expand
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
- Hiroki Kaneko, Sami Dridi, +39 authors J. Ambati
- Biology, Medicine
- Nature
- 20 January 2011
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA… Expand
The role of apoptosis in age-related macular degeneration.
- J. Dunaief, T. Dentchev, G. Ying, A. Milam
- Biology, Medicine
- Archives of ophthalmology
- 1 November 2002
OBJECTIVE
To investigate apoptosis in human age-related macular degeneration (AMD).
METHODS
Postmortem retinas with AMD and normal retinas were studied by terminal deoxynucleotidyl transferase dUTP… Expand
Retinal remodeling triggered by photoreceptor degenerations
- B. Jones, C. Watt, +6 authors R. Marc
- Biology, Medicine
- The Journal of comparative neurology
- 8 September 2003
Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It has long been assumed that the surviving neural retina is largely resistant to this sensory… Expand
Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis.
- A. Santos, M. Humayun, +4 authors A. Milam
- Biology, Medicine
- Archives of ophthalmology
- 1 April 1997
OBJECTIVE
To determine the extent of preservation in the inner retina in retinitis pigmentosa (RP).
METHODS
We analyzed sectioned maculae of 21 postmortem eyes with RP and 19 age-matched, normal,… Expand
Recoverin immunoreactivity in mammalian cone bipolar cells.
- A. Milam, D. Dacey, A. Dizhoor
- Biology, Medicine
- Visual neuroscience
- 1993
Human, macaque monkey, and rat retinas were immunostained with a polyclonal antibody preparation against purified recoverin, a 23-kD calcium-binding protein isolated from bovine retina that localizes… Expand
Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2.
- B. Chang, M. Dacey, +5 authors J. Heckenlively
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 November 2006
PURPOSE
To report a novel mouse model of achromatopsia with a cpfl3 mutation found in the ALS/LtJ strain.
METHODS
The effects of a cpfl3 mutation were documented using fundus photography,… Expand
Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination.
- S. Jacobson, A. V. Cideciyan, +7 authors E. Stone
- Medicine, Biology
- Human molecular genetics
- 1 May 2003
Mutations in CRB1, the human homolog of Drosophila Crumbs, cause autosomal recessive blinding disorders of the retina. Whereas Crumbs is implicated in apical-basal epithelial polarity and… Expand