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The enigmatic role of the ankyrin repeat domain 1 gene in heart development and disease.
The accumulated evidence for the apparent multifunctional properties of this enigmatic protein, the distinct chamber-dependent regulation of ankrd1 expression patterns in the heart, both during development and cardiac injury, and ANKRD1 involvement in networks regulating adaptation of the myocardium to stress are summarized.
Russian comparative embryology takes form: a conceptual metamorphosis toward “evo‐devo”
This essay recapitulates major paths followed by the Russian tradition of what we refer to today as evolutionary developmental biology (“evo‐devo”). The article addresses several questions regarding
Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy
Increased abundance of the myocardin mRNA pool is judged to be a novel CM-related feature which, alone or in association with decreased HOP transcript levels, can be responsible for dysregulation of myocardIn-mediated gene expression in failing myocardium.
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
The new animal models described here will be key tools in determining the underlying molecular mechanisms of disease, and a need for more in-depth research from a biomedical perspective in order to establish efficient therapeutic strategies.
Esterase-like and fibronectin-like polypeptides share similar sex-cell-biased patterns in the gonad of hermaphroditic and gonochoric species of bivalve mollusks
It is strongly suggested that sex-cell-biased expression of Est-like and Fn-like polypeptides in gonad tissue is a widespread phenomenon among bivalve mollusks, despite the high diversification of their sexual patterns.
From development to evolution: the re-establishment of the "Alexander Kowalevsky Medal".
The Saint Petersburg Society of Naturalists has reinstated the Alexander O. Kowalevsky Medal, the Russian comparative embryologist whose studies on amphioxus, tunicates and germ layer homologies pioneered evolutionary embryology and confirmed the evolutionary continuity between invertebrates and vertebrates.
Sexual differentiation of reproductive tissue in bivalve molluscs: identification of male associated polypeptide in the mantle of Mytilus galloprovincialis Lmk.
We have addressed the question of sexual reproductive tissue dimorphism in bivalve molluscs, Mytilus galloprovincialis Lmk, which is a stable gonochoric species although with no apparent differences
Retrospective immunofluorescence of specific antigens in stained and balsam embedded sections of the developing amphibian lens
A modification of the indirect immunofluorescent method is proposed for the detection of specific proteins in sections of the developing amphibian lens that were attached using egg albumin, stained
Unusual gangliosides of eggs and embryos of the sea urchin Strongylocentrotus intermedius. Structure and density-dependence of surface localization.
The surface localization of the gangliosides in embryos incubated at different cell densities was studied and the intensity of the immunofluorescence was found to increase with decreasing cell density, indicating a different surface organization in sparse and dense embryos.