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Increased susceptibility of microcytic red blood cells to in vitro oxidative stress
Abstract: Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated α‐ or β‐globin chains, intracellular iron overload and lowExpand
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Slow infusion of vincristine in the treatment of refractory thrombocytopenic purpura.
Eight patients with idiopathic thrombocytopenic purpura (ITP), who were refractory to glucocorticoid therapy, were given slow infusions of vincristine (VCR) over a 4- to 6-hour period at weeklyExpand
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Circulating Ki67 positive lymphocytes in multiple myeloma and benign monoclonal gammopathy.
AIMS--To estimate the proportion and nature of the proliferating (Ki67+) circulating lymphocytes in a series of patients with multiple myeloma and monoclonal gammopathy of unknown significance (MGUS)Expand
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Rapid detection of Spanish (delta beta)zero-thalassemia deletion by polymerase chain reaction.
delta beta-Thalassemia and hereditary persistence of fetal hemoglobin (HPFH) are inherited disorders characterized by the persistent synthesis of fetal hemoglobin (HbF) during adult life. The SpanishExpand
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Rapid detection of Spanish (delta beta)zero-thalassemia deletion by polymerase chain reaction.
delta beta-Thalassemia and hereditary persistence of fetal hemoglobin (HPFH) are inherited disorders characterized by the persistent synthesis of fetal hemoglobin (HbF) during adult life. The SpanishExpand
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Immunological phenotype of plasma cells in monoclonal gammopathy of undetermined significance
Dear Sir: The differentiation of monoclonal gammopathy of undetermined significance (MGUS) from multiple myeloma (MM) is fraught with difficulty when the monoclonal protein is recognized. A number ofExpand
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FEMALE PREDOMINANCE IN MEGAKARYOBLASTIC TRANSFORMATION OF CHRONIC MYELOGENOUS LEUKEMIA
We have recently seen a 70-yr-old woman with a megakaryoblastic transformation of chronic myelogenous leukemia (CML), 4 yr after diagnosis of a myeloproliferative disorder. In November 1987 theExpand