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Clathrin- and caveolin-1–independent endocytosis
TLDR
Results revealed the existence of a virus-activated endocytic pathway from the plasma membrane to the ER that involves neither clathrin nor caveolae and that can be activated also in the presence of cav-1.
Assembly and trafficking of caveolar domains in the cell
TLDR
It is found that when activated by simian virus 40 (SV40), a nonenveloped DNA virus that uses caveolae for cell entry, the fraction of mobile Caveolae was dramatically enhanced both in the plasma membrane and in the caveosome, an intracellular organelle that functions as an intermediate station in caveolar endocytosis.
Intracellular Assembly and Secretion of Recombinant Subviral Particles from Tick-Borne Encephalitis Virus
TLDR
The results suggest that incorporation of prM and E into RSPs occurs at the ER membrane without other viral elements being required, followed by rapid transport along the compartments of the secretory pathway and secretion.
The Transitional ER Defines a Boundary for Quality Control in the Secretion of tsO45 VSV Glycoprotein
TLDR
Analyzing the trafficking of the temperature‐sensitive, thermo‐reversible folding mutant of vesicular stomatitis virus glycoprotein in VERO cells indicates that quality control took place in the ER and in theER transitional elements, but not in the VTCs or the Golgi complex.
The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures.
TLDR
In 4 of 14 cell cultures tested, the presence of the primary virus receptor CAR was associated with the high transduction efficiency phenotype when using the B7-1- and IL-12-expressing viruses at a relatively low multiplicity of infection (MOI).
Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey
TLDR
To examine the prevalence and impact of heavy menstrual bleeding (HMB) among women in Europe, and their experience of HMB assessment and management, a large sample of women from around Europe have been surveyed.
Essential Role of Patient Blood Management in a Pandemic: A Call for Action
TLDR
This multinational and diverse group of authors issue this “Call to Action” underscoring “The Essential Role of Patient Blood Management in the Management of Pandemics” and urging all stakeholders and providers to implement the practical and commonsense principles of PBM and its multiprofessional and multimodality approaches.
Evaluation of a Single Dose of Ferric Carboxymaltose in Fatigued, Iron-Deficient Women – PREFER a Randomized, Placebo-Controlled Study
TLDR
Although more side effects were reported compared to placebo, FCM can be an effective alternative in patients who cannot tolerate or use oral iron, the common treatment of iron deficiency, and a normal iron status should be maintained independent of hemoglobin levels.
Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP)
TLDR
During late-stage pregnancy, FCM may be a more appropriate option than first-line oral iron for rapid and effective anemia correction, with additional benefits for vitality and social functioning.
PREPARE: the prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery A multicentre, observational study
TLDR
Most patients who underwent elective orthopaedic surgery had normal preoperative Hb levels but became anaemic after the procedure, and those who were anaemic prior to surgery had an increased intraoperative transfusion risk and postoperative complication rate.
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