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5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Morphometrical analyses showed reduced gray matter volume in short-allele carriers in limbic regions critical for processing of negative emotion, particularly perigenual cingulate and amygdala, and relative uncoupling of this circuit.
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Hierarchical Organization of Human Cortical Networks in Health and Schizophrenia
It is proposed that the topological differences between divisions of normal cortex may represent the outcome of different growth processes for multimodal and transmodal networks and that neurodevelopmental abnormalities in schizophrenia specifically impact multi-modal cortical organization.
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
Evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus, and these neural characteristics predicted lower levels of reward dependence in male risk allele carriers.
The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
It is shown that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
A meta-analysis of all available neuroimaging studies of rs4680 shows significant association between the COMT genotype and prefrontal activation, and meta-analytical evidence for a neural substrate for the pleiotropic behavioral effects of COMT genetic variation is found.
Neural mechanisms of genetic risk for impulsivity and violence in humans.
The data identify differences in limbic circuitry for emotion regulation and cognitive control that may be involved in the association of MAOA with impulsive aggression, suggest neural systems-level effects of X-inactivation in human brain, and point toward potential targets for a biological approach toward violence.
Test–retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures
This study provides methodological recommendations which allow the computation of sufficiently robust markers of network organization using graph metrics derived from fMRI data at rest using several commonly used measures from the field of graph theory.
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (SNPs) that covered the