A. Messerschmidt

Publications181
h-index44
Citations7,684
Highly Influential Citations216
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The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships.
TLDR
The relationships suggest that laccase, like ascorbate oxidase, has a mononuclear blue copper in domain 3 and a trinuclear copper between domain 1 and 3 and ceruloplasmin has mon onuclear copper ions in domains 2, 4 and 6 and atrinuclear Copper between domains 1 and 6. Expand
Determinants of Enzymatic Specificity in the Cys-Met-Metabolism PLP-Dependent Enzyme Family: Crystal Structure of Cystathionine γ-Lyase from Yeast and Intrafamiliar Structure Comparison
TLDR
The crystal structure of cystathionine γ-lyase (CGL) from yeast has been solved by molecular replacement at a resolution of 2.6 å and a structure comparison with other family members revealed surprising insights into the tuning of enzymatic specificity between the different family members. Expand
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis
TLDR
This modelled transmembrane complex provides a structural explanation for the uncoupling of haem biosynthesis observed in variegate porphyria patients and in plants after inhibiting PPO. Expand
Structure of cytochrome c nitrite reductase
TLDR
By comparing the haem arrangement of this nitrite reductase with that of other multihaem cytochromes, this work has been able to identify a family of proteins in which the orientation of haem groups is conserved whereas structure and function are not. Expand
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase.
TLDR
A working hypothesis for the reaction mechanism of this multiheme enzyme which carries a novel lysine-coordinated heme group (Fe-Lys) is presented and it is proposed that nitrite reduction starts with a heterolytic cleavage of the N-O bond. Expand
Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A.
TLDR
The crystal structure of CBL from E. coli has been solved using MIR phases in combination with density modification and suggests that Lys210, the PLP-binding residue, mediates the proton transfer between C alpha and S gamma. Expand
Multi-Copper Oxidases
Earlier times in multi-copper oxidase research versus recent results from Goteborg, B. Malmstrom spatial structures of the multi-copper oxidases ascorbate oxidase, laccase and related proteins -… Expand
Refined crystal structure of ascorbate oxidase at 1.9 A resolution.
The crystal structure of the fully oxidized form of ascorbate oxidase (EC 1.10.3.3) from Zucchini has been refined at 1.90 A (1 A = 0.1 nm) resolution, using an energy-restrained least-squares… Expand
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
TLDR
The crystal structure of the catalytic domain of atypical PKCiota in complex with the bis(indolyl)maleimide inhibitor BIM1 has been determined at 3.0A resolution and provides the architecture of the turn motif phosphorylation site, which is characteristic for PKCs and PKB/AKT, and is completely different from that in PKA. Expand
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.
TLDR
It is proposed that zinc affects the hK4 active site via the salt-bridge formed between the N terminus and Asp194 required for a functional active site, which explains the observed specificity of hK 4 for the P1 to P4 substrate residues. Expand
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