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- Publications
- Influence
Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer
- S. Julien, A. Merino-Trigo, +28 authors C. Berthet
- Medicine
- Clinical Cancer Research
- 23 July 2012
Purpose: Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and advanced preclinical models. Our consortium joins efforts to extensively develop and… Expand
Intracellular sorting and transport of proteins.
- C. van Vliet, E. Thomas, A. Merino-Trigo, R. Teasdale, P. Gleeson
- Biology, Medicine
- Progress in biophysics and molecular biology
- 1 September 2003
The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to direct… Expand
Localization and post-Golgi trafficking of tumor necrosis factor-alpha in macrophages.
- W. Shurety, A. Merino-Trigo, D. Brown, D. Hume, J. Stow
- Biology, Medicine
- Journal of interferon & cytokine research : the…
- 2000
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine secreted by activated macrophages. In this study, we examined the intracellular distribution and trafficking of TNF-alpha.… Expand
Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation
- A. Merino-Trigo, M. Kerr, +4 authors P. Gleeson
- Biology, Medicine
- Journal of Cell Science
- 15 December 2004
Sorting nexins are a large family of proteins that contain the phosphoinositide-binding Phox homology (PX) domain. A number of sorting nexins are known to bind to PtdIns(3)P, which mediates their… Expand
Abstract 1198: Characterization of a novel maytansinoid-antibody-drug conjugate targeting LAMP1 expressed at the surface of tumor cells
- Yves Baudat, B. Cameron, +20 authors V. Blanc
- Chemistry
- 15 July 2016
Lysosome-associated membrane protein 1 (LAMP1), one of the most abundant protein expressed at the membrane of lysosomes, is a type I transmembrane protein involved in the maintenance of lysosome… Expand
The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models
- C. Clémenson, E. Jouannot, A. Merino-Trigo, Chantal Rubin-Carrez, E. Deutsch
- Medicine
- Investigational New Drugs
- 1 April 2013
SummaryTargeting tumor vasculature is an emerging strategy in cancer treatment. Promising results have been shown in preclinical studies when vascular disrupting agents (VDAs) are used in combination… Expand
Abstract 4169: CReMEC initiative: Characterization of patient-derived colorectal tumor models and correlation with patient profile
- S. Julien, A. Merino-Trigo, +20 authors C. Berthet
- Medicine
- 15 April 2010
Well characterized models representing the heterogeneity of human colorectal cancers (CRC) are needed to develop effective therapeutic agents. Establishment of such tools will allow a better… Expand
Review Intracellular sorting and transport of proteins
- C. V. Vliet, E. Thomas, A. Merino-Trigo, R. Teasdale, P. Gleeson
- Biology
- 2003
The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to direct… Expand
Abstract 2785: Development program of patient tumor tissue bank to support the drug and target discovery.
- M. D. Boisferon, F. Bichat, +5 authors P. Vrignaud
- Medicine
- 15 April 2013
Background: The humanization of mice with various tissues named Chi-mice® aimed to reproduce the human situation to be more predictive than conventional models. Despite significant progress in… Expand