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Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications.
Dendrimers are members of a versatile, fourth new class of polymer architecture (i.e. dendritic polymers after traditional linear, crosslinked and branched types). Typically, dendrimers are used asExpand
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Transfer of PAMAM dendrimers across human placenta: prospects of its use as drug carrier during pregnancy.
Dendrimers offer significant potential as nanocarriers for targeted delivery of drugs and imaging agents. The objectives of this study were to evaluate the transplacental transport, kinetics andExpand
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Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation.
Local intravaginal drug therapy is preferred for treatment of ascending genital infections during pregnancy. In the present study, an in situ forming biodegradable hydrogel for sustained release ofExpand
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Transport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates.
Dendrimers are emerging as promising topical antimicrobial agents, and as targeted nanoscale drug delivery vehicles. Topical intravaginal antimicrobial agents are prescribed to treat the ascendingExpand
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Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers.
Dendrimers have emerged as topical microbicides to treat vaginal infections. This study explores the in vitro, in vivo antimicrobial activity of PAMAM dendrimers, and the associated mechanism.Expand
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Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries.
Doxycycline hydrogels containing reversible disulfide crosslinks were investigated for a dermal wound healing application. Nitrogen mustard (NM) was used as a surrogate to mimic the vesicant effectsExpand
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Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil.
Cefuroxime axetil (CA) has exhibited interactions with the polymers hydroxypropyl methylcellulose phthalate, cellulose acetate trimellitate, and Eudragit E resulting in the generation of unacceptableExpand
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Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds.
Half mustard (CEES) and nitrogen mustard (NM) are commonly used surrogates and vesicant analogs of the chemical warfare agent sulfur mustard. In the current study, in situ forming poly(ethyleneExpand
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Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications.
Dendrimers have emerged as multifunctional carriers for targeted drug delivery, gene delivery and imaging. Improving the functional versatility at the surface for carrying multiple conjugationExpand
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Mechanistic investigations of phase behavior in Eudragit E blends.
Blends of Eudragit E (EE) and polymeric excipients using thermal analysis and FTIR spectroscopy were examined. The interactions amongst the blend components were quantified in terms of parameters K1Expand
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