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Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes
TLDR
Results demonstrate that melatonin administration decreases the percentage of damaged cells, porphyrin synthesis, and aminolevulinate synthase (ALA‐S) mRNA levels and increases the mRNA levels for manganese superoxide‐dismutase and copper‐zinc superoxide dismutase.
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Melatonin stimulates brain glutathione peroxidase activity
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Melatonin increases gene expression for antioxidant enzymes in rat brain cortex
TLDR
Melatonin increases gene expression for antioxidant enzymes in rat brain cortex in a manner similar to that found in humans, according to Munksgaard et al. (1998).
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Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks
TLDR
Melatonin should be considered as a component of the antioxidative defense system in this avian species because of its ability to stimulate glutathione peroxidase activity, and reduce the generation of highly toxic hydroxyl radicals by metabolizing its precursor, hydrogen peroxide.
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Melatonin As a Free Radical Scavenger: Implications for Aging and Age‐Related Diseases a
TLDR
This recently discovered function of melatonin establishes a role for this indole in every organism, and indeed in every cell, from the most primitive members of the animal kingdom up to and including the was shown to be a hormone produced in and secreted from the mammalian pineal gland.
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Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence
TLDR
The results of these studies suggest that melatonin may interact with nuclear proteins and that the indole may have an important function at the nuclear level in a variety of mammalian tissues.
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Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver
TLDR
Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver indicates high affinity for melatonin in the nucleus of the liver of rats infected with EMT.
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Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
TLDR
The administration of exogenous melatonin resulted in a marked increase in the nuclear melatonin content without a concomitant change in the cytosolic fraction, and its location in the nucleus suggests possible genomic actions.
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The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes
TLDR
Investigative efforts should be directed to the possible role of melatonin in inhibiting cell death in tissues other that the thymus, since apoptosis is a possible mechanism involved in neuronal death shown in several neurodegenerative diseases such as Parkinson or Alzheimer's diseases.
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N-acetyltransferase activity and indole contents of the male Syrian hamster Harderian gland: changes during the light:dark cycle.
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