• Publications
  • Influence
Chromatography-mass spectrometry studies on the metabolism of synthetic cannabinoids JWH-018 and JWH-073, psychoactive components of smoking mixtures.
TLDR
Using gas and liquid chromatography-mass spectrometry, a series of metabolites in urine samples from humans and rats were identified that were products of the following reactions: mono- and dihydroxylation of the parent compounds with hydroxyl groups located at aromatic and aliphatic residues. Expand
Gas and liquid chromatography-mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures.
TLDR
The detection of the mono- and dihydroxylated metabolites of JWH-250 in urine and serum samples by GC-MS and LC-MS/MS proved to be effective in determining consumption of this drug. Expand
The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography - mass spectrometry.
TLDR
Using gas chromatography-mass spectrometry (GC-MS), six metabolites were identified in post-ingestion samples of AM-694, a synthetic indole-based cannabimimetic, and one metabolite (a product of hydrolytic defluorination) was also identified in urine samples from two individuals admitted to hospital suffering from suspected drug overdoses. Expand
The identification of the urinary metabolites of 3-(4-methoxybenzoyl)-1-pentylindole (RCS-4), a novel cannabimimetic, by gas chromatography-mass spectrometry.
TLDR
The O-demethylated metabolites were found to be the most useful metabolic markers for the identification of RCS-4 ingestion. Expand
The detection of the urinary metabolites of 3-[(adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a novel cannabimimetic, by gas chromatography-mass spectrometry.
TLDR
The urinary metabolites of AB-001, a synthetic cannabimimetic identified in head shop products in Ireland in 2010, have been identified and found to be adamantane mono-hydroxylated and adamantane Mono-Hydroxylation/N-dealkylated products. Expand