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Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
Results indicate that steric repulsion between the dimethylated A2058 and desosamine ring cannot be considered as a primary reason for erm-resistance. Expand
Free‐Radical Approach to 4‐Substituted Dipicolinates
Dimethyl pyridine-2,6-dicarboxylate was selectively substituted through free-radical reactions. The substitution involves the generation of free radicals through Fenton-type reactions, followed byExpand
Calorimetric studies of ternary complexes of Ni(II) and Cu(II) nitrilotriacetic acid and N-acetyloligohistidines
Abstract The thermodynamics of Cu 2+ - and Ni 2+ -NTA binding to polypeptides containing 2–6 histidine residues in neutral buffered aqueous solutions were characterized by isothermal titrationExpand
Electrochemically controlled drug-mimicking protein release from iron-alginate thin-films associated with an electrode.
Different experimental parameters, such as the film-deposition time, concentrations of compounds and applied potentials, were varied to demonstrate that the electrodepositon and electrodissolution of the alginate composite film can be tuned to the optimum performance. Expand
Fabrication of patterned calcium cross-linked alginate hydrogel films and coatings through reductive cation exchange.
This approach allows fabrication of patterned calcium alginate hydrogels through photochemical patterning of iron(III) cross-linked alginATE hydrogel followed by the photochemical reductive exchange of iron cations to calcium. Expand
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
The potency, selectivity, and stability of pyrimidine nucleotides as P2Y(6) receptor agonists may be enhanced by modest structural changes. Expand
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.
It is determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y(14) agonist, and a role for the 2''- and 6''-hydroxyl groups of 1 in receptor recognition is indicated. Expand
Oxygen catalyzed mobilization of iron from ferritin by iron(III) chelate ligands.
Tridentate chelate ligands of 2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine family rapidly release iron from human recombinant ferritin in the presence of oxygen. The reaction is inhibited byExpand
Complementary dynamic assembly around an iron(III) cation.
A new system for the complementary coordination of two different terdentate ligands based on a 2-(hydroxyamino)-1,3,5-triazine motif around a ferric cation is reported. Prototropic switching betweenExpand
Acylation through Ketene Intermediates.
A comparison of the sensitivity of the acylation to the steric bulk of alcohols supports the presence of a pseudopericyclic pathway for the nucleophilic addition ofcohols to ketenes derived from ethyl malonic and diethylphosphonoacetic acid. Expand