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Is the forced swimming test a suitable model for revealing antidepressant activity?
This test appears to be suitable for detecting antidepressant activity in rats but not in mice, and difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. Expand
Suitability of urethane anesthesia for physiopharmacological investigations in various systems Part 1: General considerations
A peculiar characteristic of urethane is represented by its ability to induce a surgical plane of anesthesia without affecting neurotransmission in various subcortical areas and the peripheral nervous system, which makes it a suitable general anesthetic for studying neural function in both central and peripheral nervous systems. Expand
The sensory-efferent function of capsaicin-sensitive sensory neurons.
Development of drugs capable of controlling the sensory-efferent functions of the capsaicin-sensitive sensory neurons represent a new and very promising area of research for pharmacological treatment of various human diseases. Expand
The nonstop transvesical cystometrogram in urethane-anesthetized rats: a simple procedure for quantitative studies on the various phases of urinary bladder voiding cycle.
A new cystometric procedure that involves a nonstop transvesical infusion of saline in urethane-anesthetized rats permits the obtainment of a series of repetitive voiding cycles in both male and female rats. Expand
Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats.
- C. Maggi, S. Giuliani, P. Santicioli, A. Meli
- Chemistry, Medicine
- The American journal of physiology
- 1 August 1986
The mechanism(s) involved in determining the voiding cycle of the rat urinary bladder have been investigated in urethan-anesthetized animals and the reflex (hexamethonium sensitive) mechanism responsible for the generation of IPHFO is more developed in male than female rats. Expand
Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans.
Observations provide the first indication that capsaicin-sensitive structures (nerves?) may be present in the human urinary bladder as they have been shown to occur in various other species. Expand
A model to measure anticipatory anxiety in mice?
Data would seem to indicate that hyperthermia in the last animals may represent a new tool for studying the neurobiology of anticipatory(?) anxiety. Expand
Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions
Urethane anesthesia appears to be suitable for various types of studies on respiratory function and on reflex activation of motility of the urinary bladder and some sections of the intestinal tract, however, urethane produces a variety of potentially disturbing side-effects at endocrine and renal level. Expand
Prostanoids modulate reflex micturition by acting through capsaicin-sensitive afferents.
The findings support the idea that endogenous prostanoids facilitate reflex micturition by stimulating or sensitizing, directly or indirectly, the subset of bladder mechanoreceptors which is capsaicin-sensitive in adult rats. Expand
Stimulation of dopamine D-2 but not D-1 receptors reduces immobility time of rats in the forced swimming test: implication for antidepressant activity.
- F. Borsini, A. Lecci, A. Mancinelli, V. D'Aranno, A. Meli
- Chemistry, Medicine
- European journal of pharmacology
- 13 April 1988
It is indicated that activation of dopamine D-2 receptors could reduce immobility time and the anti-immobility effect of desipramine was not antagonized by SCH 23390, a D-1 receptor antagonist. Expand