A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
The application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells is reported and it is shown that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms.
Integrative analysis of 111 reference human epigenomes
It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.
The NIH Roadmap Epigenomics Mapping Consortium
The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues…
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
It is found that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene and suggests that the deregulation of this process may underlie the pathology of RT T.
Dissecting direct reprogramming through integrative genomic analysis
This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
DNA methylation: roles in mammalian development
Key concepts in the function of DNA methylation in mammals are discussed, stemming from more than two decades of research, including many recent studies that have elucidated when and whereDNA methylation has a regulatory role in the genome.
lincRNAs act in the circuitry controlling pluripotency and differentiation
It is shown that Knockdown of lincRNAs has major consequences on gene expression patterns, comparable to knockdown of well-known ES cell regulators.