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In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice.
TLDR
This approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility. Expand
The testis in immune privilege
TLDR
The role of androgens in testicular immune regulation has long been underestimated; yet, accumulating evidence now shows that they orchestrate the inhibition of proinflammatory cytokine expression and shift cytokine balance toward a tolerogenic environment. Expand
Migration inhibitory factor expression in experimentally induced endotoxemia.
TLDR
The constitutive production of MIF by several cell and tissue types together with its rapid release from intracellular pools distinguishes MIF from other cytokines or hormonal mediators and significantly expands the physiological role of this unique counter-regulator of glucocorticoid action. Expand
The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
TLDR
The results indicate that loss of Hook1 function results in ectopic positioning of microtubular structures within the spermatid and causes the azh phenotype, and the human HOOK1 gene could serve as a candidate gene for male infertility due to teratozoospermia or decapitation defects. Expand
Expression of mitochondrial marker proteins during spermatogenesis.
TLDR
This review pays particular attention to transiently expressed mitochondrial proteins such as hsp60, Lon protease, sulphydryl oxidase and cytochrome ct which play a unique role in germ cell mitochondria development. Expand
Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor.
TLDR
Macrophage migration inhibitory factor is reported here that the insulin-secreting beta cell of the islets of Langerhans expresses MIF and that its production is regulated by glucose in a time- and concentration-dependent manner. Expand
Cytokines and the immune-testicular axis.
TLDR
The aim of this review is to provide a very brief summary of the extensive literature dealing with cytokines in testicular biology, and to follow this with some speculation concerning the significance of these molecules in interactions between the immune system and the testis. Expand
Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells.
TLDR
In vitro generation of a germ cell line (SSC1) from the pluripotent teratocarcinoma cells by a novel promoter-based sequential selection strategy is reported and it is shown that the SSC1 cell line form mature seminiferous tubule structures, and support spermatogenesis after transplantation into recipient testes. Expand
The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat
TLDR
It is argued that blocking MIF activity may be of benefit in the treatment of human rapidly progressive glomerulonephritis, and suggested that MIF may be important in immune-mediated disease generally. Expand
The Small Heat Shock Protein ODF1/HSPB10 Is Essential for Tight Linkage of Sperm Head to Tail and Male Fertility in Mice
TLDR
The results suggest that ODF1, besides being involved in the correct arrangement of mitochondrial sheath and outer dense fibers, is essential for rigid junction of sperm head and tail, and might account for some of the cases of human infertility with decapitated sperm heads. Expand
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