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Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone
Mitochondrial toxins such as the complex 1 inhibitor rotenone are widely used as pesticides and may be present in military environments. Administration of rotenone can induce biochemical andExpand
Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projections to forebrain
SummaryThe colocalization of neurotensin- and cholecystokinin-like immunoreactivities was demonstrated in neurons of the ventral mesencephalon of the rat by using a double-labeling indirectExpand
Partial denervation of the medial gastrocnemius muscle results in growth-associated protein-43 immunoreactivity in sprouting axons and schwann cells
Regeneration in the mammalian peripheral nervous system following nerve injury is associated with the upregulation of a developmentally regulated phosphoprotein, growth-associated protein-43Expand
Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons
Treatment of degenerating basal forebrain cholinergic neurons with nerve growth factor (NGF) in Alzheimer's disease has long been contemplated, but an effective and safe delivery method has beenExpand
Variation in the latencies and amplitudes of N400 and NA as a function of semantic priming.
The purpose of this study was to determine whether the latencies of two event-related potential (ERP) components, the NA and N400, were sensitive to semantic priming. Subjects performed a semanticExpand
Effect of GABAA receptor stimulation in the subthalamic nucleus on motor deficits induced by nigrostriatal lesions in the rat
Inhibition of the subthalamic nucleus by lesions or GABAergic agonists improves motor symptoms in monkeys or humans with a loss of nigrostriatal dopaminergic neurons, a characteristic of Parkinson'sExpand
Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons
Peripheral administration of the 5-hydroxytryptamine (5-HT)(2C/1B) agonist 1-(m-chlorophenyl)piperazine (m-CPP) produces abnormal orofacial movements in rats. We have previously shown that thisExpand
Spinal cord cultured neurons: an in vitro model to study GABA synaptic pharmacology.
In summary, spinal cord cultured neurons provide an in vitro model for studying GABA synaptic pharmacology. GABAA agonists stimulate 36Cl-influx in these cells in a concentration-dependent manner.Expand
Mechanisms of Subthalamic Dysfunction in Parkinson’s Disease
Changes in neuronal firing in the subthalamic nucleus have emerged as one of the cardinal features of Parkinson’s disease. A central role for this region in Parkinson’s disease can be inferred fromExpand
527. CERE-110, an AAV2-based vector to deliver NGF, provides trophic activity to basal forebrain cholinergic neurons in rats and cynomolgous monkeys
Numerous studies indicate that providing trophic support to degenerating basal forebrain cholinergic neurons with nerve growth factor (NGF) is a logical approach to treating mild to moderateExpand