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Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Hyperplastic liver lesions which develop following administration of hepatocarcinogens have been implicated as probable precursors for the cancers which ultimately develop. Some, and possibly all, ofExpand
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Identification and quantification of aberrant crypt foci and microadenomas in the human colon.
The objective of the present study was to determine whether aberrant crypt foci (ACF) similar to those observed in the colons of experimental animals exposed to colon carcinogens could be identifiedExpand
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Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse.
Dietary folate appears to be inversely related to colorectal cancer risk. This study investigated the effects of dietary intervention with folate or the development of intestinal polyps in Min (ApcExpand
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  • Open Access
Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.
Epidemiological and animal studies (reviewed in Y. I. Kim, J. Nutr. Biochemistry, 10: 66-88, 1999; J. B. Mason and T. Levesque, Oncology, 10: 1727-1743, 1996) suggest that dietary folate intake isExpand
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Possible mechanisms relating diet and risk of colon cancer.
Two recent developments in cancer epidemiology and experimental carcinogenesis provide the basis for two possible mechanisms relating diet and colon cancer risk. The first development is theExpand
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  • Open Access
Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring.
Intrauterine and early life exposure to folic acid has significantly increased in North America owing to folic acid fortification, widespread supplemental use, and periconceptional supplementation.Expand
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Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon.
Foci of aberrant crypts (ACF) have been identified in the unsectioned methylene blue stained rodent colons and hypothesized to represent precursor lesions of colon cancer. In the present study,Expand
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Folic Acid Supplementation Promotes Mammary Tumor Progression in a Rat Model
Folic acid supplementation may prevent the development of cancer in normal tissues but may promote the progression of established (pre)neoplastic lesions. However, whether or not folic acidExpand
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  • Open Access
Assessment of Prognostic Factors in Alcoholic Liver Disease: Toward a Global Quantitative Expression of Severity
The prognostic significance of a battery of clinical, laboratory, and histological indicators was assessed in relation to mortality risk in a 1‐year study of 253 patients with alcoholic liverExpand
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Classification of aberrant crypt foci and microadenomas in human colon.
Aberrant crypt foci (ACF) can be observed and quantified on the mucosal surface of formalin-fixed human colon resections after staining with methylene blue. To determine whether these ACF could beExpand
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  • Open Access