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Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and investigated methods for… Expand
CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.
BACKGROUND & AIMS Methylation of CpG islands is increasingly recognized as an important event in colorectal carcinogenesis. We evaluated the extent of CpG island methylation in 426 sporadic… Expand
Elective surgery after acute diverticulitis
Diverticulitis is a common condition. Practice guidelines from many organizations recommend bowel resection after two attacks. The evidence for such a recommendation is reviewed.
J ileal pouch–anal anastomosis for chronic ulcerative colitis: complications and long‐term outcome in 1310 patients
- A. Meagher, R. Farouk, R. Dozois, K. Kelly, J. Pemberton
- The British journal of surgery
- 1 June 1998
The purpose of the study was to determine the risk of postoperative complications and the functional outcome after a hand‐sewn ileal pouch–anal anastomosis (IPAA) for ulcerative colitis using a… Expand
The relationship between hypomethylation and CpG island methylation in colorectal neoplasia.
- C. Bariol, C. Suter, +4 authors R. Ward
- Biology, Medicine
- The American journal of pathology
- 1 April 2003
Tumors are often characterized by an imbalance in cytosine methylation as manifested both by hypermethylation of CpG islands and by genome hypomethylation. These epigenetic changes were assessed in… Expand
Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability.
- R. Ward, K. Cheong, Su-Lyn Ku, A. Meagher, Terence O'Connor, N. Hawkins
- Journal of clinical oncology : official journal…
- 15 October 2003
PURPOSE DNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI). In this study, we sought to… Expand
Comparison of reduced volume versus four liters sulfate-free electrolyte lavage solutions for colonoscopy colon cleansing
- J. Dipalma, B. Wolff, A. Meagher, M. Cleveland
- American Journal of Gastroenterology
- 1 October 2003
OBJECTIVE:In an attempt to improve patient tolerance for colonoscopy cleansing, a reduced volume lavage regimen with 2 L sulfate-free electrolyte lavage solution (SF-ELS, NuLYTELY, Braintree… Expand
Practice parameters for sigmoid diverticulitis.
It should be recognized that these guidelines should not be deemed inclusive of all proper methods of care or exclusive of methods of care reasonably directed to obtaining the same results. The… Expand
Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation
PURPOSE: This study was designed to compare the efficacy and patient tolerance of standard orthograde bowel preparation using 4 liters of polyethylene glycol solution with only 2 liters of… Expand
Patient and physician preferences for surgical and adjuvant treatment options for rectal cancer.
HYPOTHESIS Patients and their clinicians hold varying preferences for surgical and adjuvant treatment therapies for rectal cancer. DESIGN Preferences were determined using the Prospective Measure… Expand