A. Mcneilly

Publications591
h-index78
Citations23,653
Highly Influential Citations664
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Measurement of dimeric inhibin B throughout the human menstrual cycle.
TLDR
Using this immunoassay, it was found that the plasma concentration of inhibin B rose rapidly in the early follicular phase to a peak of 85.2 +/- 9.6 pg/mL on the day after the intercycle FSH rise, then fell progressively during the remainder of the follicular phases, which suggests that these forms may have different physiological roles.
Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction.
TLDR
It is concluded that inhibin B is a unique testicular product that is not detectable in the sera of orchidectomized men, is responsive to FSH stimulation, and has a reciprocal relationship with serum FSH levels in men with various forms of testicular disease.
Inhibin-B: a likely candidate for the physiologically important form of inhibin in men.
TLDR
The results strongly suggest that the physiologically important form of inhibin in men is inhibin B, which has a critical effect on FSH release.
The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.
TLDR
A mutation in the subdomain 3 of the kinase domain could result in an alteration in the expression and/or phosphorylation of SMADs, resulting in the phenotype characteristic of the Booroola animals which is the 'precocious' development of a large number of small antral follicles resulting in increased ovulation rate.
Theca: the forgotten cell of the ovarian follicle.
TLDR
While the theca is an essential component of follicle development and ovulation, it is clear that thecal cells are fundamental for follicular growth, providing all the androgens required by the developing follicle(s) for conversion into estrogens by the granulosa cells.
Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulosa cells, and localization of BMP receptors in the ovary by immunohistochemistry.
TLDR
It is concluded that BMP receptors are present in sheep ovaries and that B MPs may have a role in the differentiation of granulosa cells by enhancing the action of FSH.
Indicator dilution models for the quantification of microvascular blood flow with bolus administration of ultrasound contrast agents
TLDR
The properties of the lognormal function, the gamma variatefunction, the diffusion with drift models, and the lagged normal function are reviewed and discussed, which have been used to model indicator dilution curves in different fields of medicine.
Regulation of folliculogenesis and the determination of ovulation rate in ruminants.
TLDR
The updated model has more extensive integration of the morphological, molecular and cellular events during folliculogenesis with systemic events in the whole animal and incorporates knowledge on factors that influence oocyte quality and the critical roles of the oocyte in regulating follicular development and ovulation rate.
Suppression of follicular development after chronic LHRH immunoneutralization in the ewe.
TLDR
Results show that follicular development beyond 2.5 mm in the ewe is dependent on adequate stimulation by both LH and FSH, and that basal and hCG-stimulated progesterone secretion was suppressed in the follicles from LHRH-immunized ewes.
Detection of dimeric inhibin throughout the human menstrual cycle by two‐site enzyme immunoassay
TLDR
A two‐site immunoassay was developed and validated for the measurement of dimeric inhibin in plasma and subsequently measured dimeric inhibitin levels in plasma through the normal female menstrual cycle.
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