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Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis
It is suggested that oral CBD does not reduce the reinforcing, physiological, or positive subjective effects of smoked cannabis, as well as the effect of oral THC on smoked cannabis administration. Expand
A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans
This double-blind, placebo-controlled laboratory study provides the first evidence that propranolol administration following CCE may modulate memories for learning processes that subserve cocaine craving/cue reactivity in CD humans. Expand
A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder.
- A. McRae-Clark, R. Carter, T. Killeen, M. Carpenter, K. White, K. Brady
- Psychology, Medicine
- The American journal on addictions
- 1 November 2010
It is suggested that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population of marijuana-dependent adults. Expand
A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.
This is the first randomized controlled trial of pharmacotherapy for cannabis dependence in any age group to yield a positive primary cessation outcome in an intent-to-treat analysis, and findings support NAC as a pharmacotherapy to complement psychosocial treatment for Cannabis dependence in adolescents. Expand
Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
Marijuana cue exposure and a social stressor increased craving in marijuana-dependent individuals, and completion of the TSST did not increase craving response to subsequent marijuana cue exposure. Expand
Reactivity to laboratory stress provocation predicts relapse to cocaine.
The findings provide further evidence of the ability of laboratory paradigms to predict relapse and interventions aimed at normalizing stress response, as measured using laboratory Paradigms, may prove useful in relapse prevention. Expand
Association of elevated cytokines with childhood adversity in a sample of healthy adults.
- K. Hartwell, M. M. Moran-Santa Maria, +4 authors K. Brady
- Psychology, Medicine
- Journal of psychiatric research
- 1 May 2013
The positive association between childhood trauma and basal cytokine levels supports the extant literature demonstrating the long-term impact of Childhood trauma and stress on homeostatic systems. Expand
Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial.
- A. McRae-Clark, N. Baker, +5 authors Jessica Norton
- Drug and alcohol dependence
- 1 November 2015
Buspirone was not more efficacious than placebo in reducing cannabis use, and important gender differences were noted, with women having worse cannabis use outcomes with buspirone treatment. Expand
A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults.
There is no evidence that NAC 1200mg twice daily plus CM is differentially efficacious for CUD in adults when compared to placebo plus CM, and this discrepant finding between adolescents and adults with CUD may have been influenced by differences in development, cannabis use profiles, responses to embedded behavioral treatment, medication adherence, and other factors. Expand
A randomized, placebo-controlled laboratory study of the effects of d-cycloserine on craving in cocaine-dependent individuals
The reduction of cocaine cue reactivity in the PBO group suggests that the study procedures were sufficient to produce extinction, and DCS did not facilitate extinction learning and may have enhanced craving. Expand