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The form and function of microfabric features in a variety of natural soils
A scanning electron microscope study has been undertaken of the microfabric of a variety of normally consolidated or lightly overconsolidated recent clays, silts and sands formed within the last 10...
Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies.
- G. Jayson, J. Zweit, +20 authors H. Zwierzina
- Journal of the National Cancer Institute
- 2 October 2002
BACKGROUND Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine, and various inhibitory agents, including specific antibodies, have been developed to block VEGF-stimulated… Expand
THE COLLAPSE MECHANISM IN PARTLY SATURATED SOIL
Abstract A study has been made of the metastable structure of partly saturated soilt that collapse when wetted under load. This has been done using the scanning electron microscope on air-dried… Expand
Tubulin as a Target for Anticancer Drugs: Agents which Interact with the Mitotic Spindle
Effect of inclusion properties on the behaviour of sand
The Paper describes the findings of plane strain unit cell tests on Leighton Buzzard sand with and without inclusions of aluminium foil, aluminium mesh and a non-woven melt bonded hetrofilament… Expand
The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo.
- M. Lind, A. McGown, J. Hadfield, N. Thatcher, D. Crowther, B. Fox
- Chemistry, Medicine
- Biochemical pharmacology
- 1 June 1989
The effect of ifosfamide and its metabolites on intracellular levels of glutathione in P388 cells in vitro has been studied. It is demonstrated that glutathione depletion occurs only in the presence… Expand
Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients.
Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and… Expand
Novel syntheses of cis and trans isomers of combretastatin A-4.
- K. Gaukroger, J. Hadfield, L. Hepworth, N. Lawrence, A. McGown
- Chemistry, Medicine
- The Journal of organic chemistry
- 2 November 2001
A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation of 3,4,5-trimethoxyphenylacetic acid… Expand
The role of metallothionein, glutathione, glutathione S-transferases and DNA repair in resistance to platinum drugs in a series of L1210 cell lines made resistant to anticancer platinum agents.
The glutathione contents, glutathione S-transferase activities and metallothionein contents have been measured in a series of L1210 cell lines which show decreased sensitivities to platinum drugs.… Expand
Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
- A. Jordan, J. Hadfield, N. Lawrence, A. McGown
- Biology, Medicine
- Medicinal research reviews
- 1 July 1998
Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and… Expand