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Prebiotic effects: metabolic and health benefits

The present document has been written by a group of both academic and industry experts and aims to validate and expand the original idea of the prebiotic concept, defined as the selective stimulation of growth and/or activity of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host.
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Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children.

Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients.
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Application of molecular biological methods for studying probiotics and the gut flora

  • A. McCartney
  • Biology
    British Journal of Nutrition
  • 1 September 2002
The future of molecular biology in the field of probiotics and the gut flora will, no doubt, stretch to investigations of functionality and activity of the microflora, and/or specific fractions.
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A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders.

The relatively high inter-individual variability observed suggests that subsequent studies should use defined subgroups of autistic spectrum disorders, such as regressive or late-onset autism.

Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.

Modulation of bacterial flora by increasing bifidobacteria and decreasing Desulfovibrio spp.
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An In Vitro Study of the Probiotic Potential of a Bile-Salt-Hydrolyzing Lactobacillus fermentum Strain, and Determination of Its Cholesterol-Lowering Properties

Results from this in vitro study suggest that L. fermentum KC5b is a candidate probiotic which may affect cholesterol metabolism and specifically the molar proportion of propionate and/or bile salt deconjugation are probably the major mechanism involved in the purported cholesterol-lowering properties of this strain.
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Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid

D. COUTEAU, A.L. McCARTNEY, G.R. GIBSON, G. WILLIAMSON AND C.B. FAULDS. 2001.
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Physiological and Bifidogenic Effects of Prebiotic Supplements in Infant Formulae

Stool consistency and bacterial composition of infants taking SYN1 0.8 g/dL or GOS:FOS–supplemented formula were closer to the breast-fed pattern, while during the first month of life, weight, length, intake, stool characteristics, crying, regurgitation, vomiting, adverse events, and fecal bacterial population counts increased.
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Investigation of the faecal microbiota associated with canine chronic diarrhoea.

F fibre supplementation induced changes in the canine faecal microbiota, with greater resemblance between the microbiota of chronic diarrhoea and control dogs after this dietary modulation.
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Prebiotics and resistance to gastrointestinal infections

The combined effects of prebiotics upon the lactic acid flora and anti-adhesive strategies may lead towards new dietary interventions against food safety agents.
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