• Publications
  • Influence
Hedgehog signaling requires motile cilia in the sea urchin.
TLDR
Evidence is presented that in the sea urchin, a basal deuterostome, motile cilia are required for embryonic Hh signal transduction, and the Hh receptor Smoothened (Smo) localizes to cilia during active Hh signaling, which is the first evidence that HH signaling requires motiles cilia and the first case of an organism requiring cilia outside of the vertebrate lineage. Expand
RNA degradation sculpts the maternal transcriptome during Drosophila oogenesis
TLDR
It is shown that a subset of RNAs expressed during the early stages of oogenesis is subjected to regulated degradation during oocyte specification, which helps orchestrate a germ cell-to-maternal transition by sculpting the maternal RNA contribution to the zygote. Expand
Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling
TLDR
It is observed that the perturbation of the oocyte's epigenome in early oogenesis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulation of meiotic transcription and affects female fertility. Expand
Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila
TLDR
It is found that Nipped-A is required for efficient exit from the gap phase 2 (G2) of cell cycle of the GSC daughter and for expression of a differentiation factor, bgcn, and results indicate that Tip60 complex coordinates cell cycle progression and expression of bgCN to help drive GSC daughters toward a differentiation program. Expand
Role of Chromatin Modifications in Drosophila Germline Stem Cell Differentiation.
TLDR
Together, intrinsic and extrinsic epigenetic mechanisms modulate this exquisitely balanced program of self-renewal and differentiation of germline stem cells. Expand
Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster
TLDR
The endogenous Adh locus is developmentally regulated by transcriptional interference in a tunable manner and upregulation of the distal Adh transcript led to the enrichment of histone 3 lysine 36 trimethylation over the Adh proximal promoter. Expand
MSL3 coordinates a transcriptional and translational meiotic program in female Drosophila
TLDR
It is discovered that the H3K36me3 reader Male-specific lethal 3 (MSL3) and the histone acetyltransferase complex Ada2a-containing (ATAC) cooperate with Set2 to regulate entry into meiosis in female Drosophila. Expand
Gene activity int eh carnation-light synthetic lethal inDrosophila melanogaster
TLDR
A gynandromorphic study of the carnation-light synthetic lethal revealed a site of lethal interaction (focus) in nerve tissue, interpreted in terms of a model which accounts for diminution of developmental potential as a result of irreversible gene repression rather than selective gene activation. Expand
RNA degradation is required for the germ-cell to maternal transition in Drosophila
TLDR
It is shown that a subset of RNAs expressed during the early stages of oogenesis is subjected to regulated degradation during oocyte specification, which helps orchestrate a germ cell-to-maternal transition that gives rise to the maternal contribution to the zygote. Expand
...
1
2
...