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Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita
The draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, is reported, providing insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.
Genomic Insights into the Origin of Parasitism in the Emerging Plant Pathogen Bursaphelenchus xylophilus
A high-quality draft genome sequence from an inbred line of B. xylophilus is presented, and the lack of proteins homologous to effectors from other plant parasitic nematodes confirms the distinctive molecular basis of plant parasitism in the Bursaphelenchus lineage.
RNAi Effector Diversity in Nematodes
While RNA interference (RNAi) has been deployed to facilitate gene function studies in diverse helminths, parasitic nematodes appear variably susceptible. To test if this is due to inter-species…
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
flp gene disruption in a parasitic nematode reveals motor dysfunction and unusual neuronal sensitivity to RNA interference
- M. Kimber, S. McKinney, S. McMaster, T. Day, C. Fleming, A. Maule
- BiologyThe FASEB Journal
- 1 April 2007
In attempts to evaluate flp function in G. pallida, it is discovered that, unlike in C. elegans, these genes are readily susceptible to RNAi, paving the way for the investigation of RNAi‐mediated flp gene silencing as a novel plant parasite control strategy.
Flatworm nerve–muscle: structural and functional analysis
Platyhelminthes occupy a unique position in nerve–muscle evolution, being the most primitive of metazoan phyla. Essentially, their nervous system consists of an archaic brain and associated pairs o...
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration.
The FLP-side of nematodes.