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Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita
The draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, is reported, providing insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies. Expand
Genomic Insights into the Origin of Parasitism in the Emerging Plant Pathogen Bursaphelenchus xylophilus
A high-quality draft genome sequence from an inbred line of B. xylophilus is presented, and the lack of proteins homologous to effectors from other plant parasitic nematodes confirms the distinctive molecular basis of plant parasitism in the Bursaphelenchus lineage. Expand
RNAi Effector Diversity in Nematodes
While RNA interference (RNAi) has been deployed to facilitate gene function studies in diverse helminths, parasitic nematodes appear variably susceptible. To test if this is due to inter-speciesExpand
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
The data reveal that nematode FLPs encompass the most complex neuropeptide family known within the metazoa, and individual FLPs and FLP motifs are highly conserved across the nematodes with little evidence for inter-clade or inter-lifestyle variation, supporting their fundamental role in free-living and parasitic species. Expand
flp gene disruption in a parasitic nematode reveals motor dysfunction and unusual neuronal sensitivity to RNA interference
In attempts to evaluate flp function in G. pallida, it is discovered that, unlike in C. elegans, these genes are readily susceptible to RNAi, paving the way for the investigation of RNAi‐mediated flp gene silencing as a novel plant parasite control strategy. Expand
Flatworm nerve–muscle: structural and functional analysis
Platyhelminthes occupy a unique position in nerve–muscle evolution, being the most primitive of metazoan phyla. Essentially, their nervous system consists of an archaic brain and associated pairs o...
Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
The role of antibody and T cell responses in mediating protection and the prospects of the cathepsin Ls in the development of first generation recombinant liver fluke vaccines are reviewed. Expand
The FLP-side of nematodes.
Current knowledge of nematode FLP signalling is summarized and much work is needed to clarify the functional aspects of FLPs and how these peptides exert their effects at the organismal level. Expand
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration.
The successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs) resulted in marked reductions in target transcript levels and significant diminution in the encoded proteins in the gut. Expand
Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology
Part I: Phylogeny, Genetics and Transcriptomes * The Evolution of Parasitism in Flatworms * Genomes and Genomics of Parasitic Flatworms. Expand