Author pages are created from data sourced from our academic publisher partnerships and public sources.
EO9: relationship between DT-diaphorase levels and response in vitro and in vivo.
EO9 [3-hydroxy-5-aziridinyl-1-methyl-2(1H-indole-4,7-dione)-prop-beta-en- alpha-ol] was selected for clinical trial in Europe because of its preclinical profile but also because of its distinct… Expand
Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid.
5,6-Dimethylxanthenone-4-acetic acid (5,6-MeXAA) is a fused tricyclic analogue of flavone acetic acid (FAA) which was developed in an attempt to improve on the activity of FAA. Previous studies have… Expand
Morphological and immunological observations on the effects of hexadecylphosphocholine (HPC) in nude mice bearing MT-1 breast cancer xenografts.
Hexadecylphosphocholine (HPC) is active against experimental and clinical breast cancer in vivo but the precise mechanisms involved are not fully understood. Studies in this and other laboratories… Expand
Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue.
- P. Loadman, A. Matthew, J. Mccormick, R. Mcelhinney, M. Bibby
- Chemistry, Medicine
- Anti-cancer drug design
- 1 March 1996
The original design of the previously described molecular combinations of 5-fluorouracil (5-FU) and a chloroethyl nitrosourea (CNU) moiety was on the basis that a single drug would be able to deliver… Expand
Pre-clinical evaluation of a novel chloroethylating agent, Clomesone.
The in vitro activity of the novel chloroethylating agent, Clomesone, was investigated in a panel of established murine and human tumour cell lines. In vivo anti-tumour activity was examined against… Expand
Hyperoxic pretreatment improves survival and slows tumor growth.
Pharmacokinetic studies of chloroethylnitrosocarbamoyl-amino acid derivatives in vivo and in vitro.
The in vitro chemosensitivity of MAC 15A ascites cells to CNC-alanylalanine and CNC-glycinemethylamide was assessed using a clonogenic assay system. In vitro stability studies and in vivo… Expand
Anti-tumour activity and bone marrow toxicity of chloroethylnitrosocarbamoyl-amino acid derivatives.
The anti-tumour activity of a series of chloroethylnitrosoureas derived from the amino acids alanine and glycine was examined in 3 transplantable adenocarcinomas of the mouse colon. In addition, bone… Expand