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Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver.
TLDR
The results suggested that carboxylesterases pI 5.3 and 4.5 may be involved in the metabolism of various drugs containing an ester-linkage, and that the deduced amino acid sequence from the cDNA registered as human car boxylesterase (hCE-2) in GenBank is identical to that from cDNA for HU1.
Rolling Circle Translation of Circular RNA in Living Human Cells
TLDR
It is demonstrated that the circular RNA is efficiently translated in living human cells to produce abundant protein product by RCA mechanism, suggesting that translation of exonic circular RNAs present in human cells is more probable than previously thought.
Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
TLDR
Data indicate a dual role of hSMUG1 as a backup enzyme for UNG and a primary repair enzyme for a subset of oxidized pyrimidines such as fU, hmU, and hoU.
Clusterin, an Abundant Serum Factor, Is a Possible Negative Regulator of MT6-MMP/MMP-25 Produced by Neutrophils*
TLDR
Interestingly, 73- and 70-kDa proteins were co-purified with the soluble MT6-MMP by forming stable complexes that were identified as clusterin, a major component of serum, by N-terminal amino acid sequencing, which may act as a negative regulator of MT6 -MMP in vivo.
Antitumor activity and novel DNA‐self‐strand‐breaking mechanism of CNDAC (1‐(2‐C‐cyano‐2‐deoxy‐β‐d‐ARABINO‐Pentofuranosyl) cytosine) and its N4‐palmitoyl derivative (CS‐682)
TLDR
CNDAC is converted to CNDACMP by deoxycytidine kinase and that the resulting CNDacTP incorporated into a DNA strand as CND ACMP may induce DNA‐self‐strand‐breakage, which may contribute to the potent antitumor activity of CS‐682.
Antitumor activity of sugar‐modified cytosine nucleosides
TLDR
The design, in vitro cytotoxicity, in vivo antitumor activity, metabolism and mechanism of action of sugar‐modified cytosine nucleosides, such as (2′S)‐2′‐deoxy‐2‐methylene‐β‐D‐erythro‐pentofuranosyl)cytosine (ECyd), developed by the groups, are discussed here.
Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil
TLDR
ECyd had strong and selective antitumor activity against the human tumor xenografts.
Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.
TLDR
Almost all of the nucleosides showed anti-HIV-1 activities, they were also cytotoxic to the host cells (MT-4) and antiviral activities against HSV-1,HSV-2, and HIV-1 in vitro were examined.
Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine.
TLDR
Results suggest that fC may induce the transition mutation C.G-->T.A and the transversion mutation C,G-->A.T during DNA synthesis, which is similar to that induced by DNA polymerase I.
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