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Preeclampsia: increased expression of soluble ADAM 12
Preeclampsia is a multisystemic pregnancy-associated disease affecting about 3–7% of pregnancies worldwide and is still a principal cause of fetal and maternal morbidity and mortality. To identifyExpand
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Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T‐cell responses
Immune tolerance toward the semiallogeneic fetus plays a crucial role in the maintenance of pregnancy. Myeloid‐derived suppressor cells (MDSCs) are innate immune cells characterized by their abilityExpand
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A Stable Niche Supports Long‐Term Maintenance of Human Epidermal Stem Cells in Organotypic Cultures
Stem cells in human interfollicular epidermis are still difficult to identify, mainly because of a lack of definitive markers and the inability to label human beings for label‐retaining cells (LRCs).Expand
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Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer
2530 Background: Ertumaxomab is an intact bispecific monoclonal antibody targeting HER2 and CD3. The heavy chain is composed of murine IgG2a and rat IgG2b subclasses with strong binding to activatoryExpand
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Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors
Background: Glucocorticoids have been used widely in conjunction with cancer therapy due to their ability to induce apoptosis in hematological cells and to prevent nausea and emesis. However, recentExpand
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Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function
Nosocomial bacterial infections (NBI) and necrotizing enterocolitis (NEC) are among the main reasons for death in preterm infants. Both are often caused by bacteria coming from the infected infant’sExpand
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[Screening for mental stress and the wish for psychological support in patients with breast cancer].
OBJECTIVES The study explores whether breast-cancer patients who request psychosocial support have higher psychological strain compared to those who do not. We also explored whether scores on HADS-DExpand
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HLA‐G promotes myeloid‐derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4
Establishing and maintaining maternal‐fetal tolerance is essential for a successful pregnancy; failure of immunological adaptation to pregnancy leads to severe complications such as abortion orExpand
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A CD80-transfected human breast cancer cell variant induces HER-2/neu–specific T cells in HLA-A*02–matched situations in vitro as well as in vivo
Adjuvant treatment is still only working in a small percentage of breast cancer patients. Therefore, new strategies need to be developed. Immunotherapies are a very promising approach because theyExpand
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Pre-existing T-cell immunity against mucin-1 in breast cancer patients and healthy volunteers
Purpose: There is evidence that some tumor patients are able to generate tumor-associated antigen (TAA)-specific T-cell immunity spontaneously. However, little is understood about the existence andExpand
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