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Moenomycin A: The role of the methyl group in the moenuronamide unit and a general discussion of structure-activity relationships
Abstract Two disaccharide analogues 1b and 17a of moenomycin A have been synthesized and their antibiotic and transglycosylase-inhibiting properties have been determined. The results permit for the… Expand
Structures of some moenomycin antibiotics - inhibitors of peptidoglycan biosynthesis
Abstract Isolation, structural assignment, and antibiotic efficiency of the new moenomycin antibiotics C3 (1b) and C4 (1c) is decribed. The previously published structure of pholipomycin (1d) is… Expand
The first moenomycin antibiotic without the methyl-branched uronic acid constituent.- Unexpected structure activity relations
Abstract Isolation and structure elucidation of a new moenomycin antibiotic (C1, 1e) that lacks the branching methyl group in the 4-position of unit F are reported. The smallest antibiotically active… Expand
A structurally and biogenetically interesting moenomycin antibiotic
Isolation and structure elucidation of a new moenomycin antibiotic (A12, 1a) is reported that differs from moenomycin A by lack of the branching methyl group and by the configuration at C-4 of unit… Expand
Moenomycin A: reactions at the lipid part. New structure-activity relations
Abstract Methods for the removal and the oxidation of the lipid moiety of the antibiotic moenomycin A have been studied. Combined with biochemical studies, the results demonstrate that antibiotic… Expand
Ala(0)-actagardine, a New Lantibiotic from Cultures of Actinoplanes liguriae ATCC 31048.
Oxidation and dehalogenation of 4-chlorophenylacetate by a two-component enzyme system from Pseudomonas sp. strain CBS3.
In cell-free extracts from Pseudomonas sp. strain CBS3 the conversion of 4-chlorophenylacetate to 3,4-dihydroxyphenylacetate was demonstrated. By Sephacryl S-200 chromatography two protein fractions,… Expand
Degradation of 4-chlorophenylacetic acid by a Pseudomonas species.
Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid… Expand
Mikrobieller Abbau von 4-Chlorphenylessigsäure. Chemische Synthese von 3-Chlor-4-hydroxy-, 4-Chlor-3-hydroxy- und 4-Chlor-2-hydroxyphenylessigsäure.
Synthesis of a trisaccharide analogue of moenomycin A12 Implications of new moenomycin structure-activity relationships
Abstract A trisaccharide analogue of moenomycin A, 9a, has been synthesized and has found to be antibiotically inactive. This compound differs from an active compound, 9b, solely by the exchange… Expand