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Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin
TLDR
The high in vitro activity of cefquinome is reflected by its high in vivo efficacy against experimental septicemia due to different gram-positive and gram-negative bacteria.
Chemotherapeutic activity of levofloxacin (HR 355, DR-3355) against systemic and localized infections in laboratory animals.
TLDR
DT-S levofloxacin was up to four times more effective and produced a more pronounced bactericidal effect against the pathogens in vivo than the reference compounds and despite possessing a similar, if not lesser, in-vitro activity against the infecting pathogens.
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?
TLDR
Comparison with tunicamycin-treated cells indicated that peptidoglycan rather than teichoic acid metabolism is primarily affected, which suggests that mersacidin acts on a novel target, which opens new perspectives for the treatment of methicillin-resistant S. aureus.
Pharmacokinetics of cefpirome administered intravenously or intramuscularly to rats and dogs.
TLDR
The bioavailability of cefpirome in rats and dogs after both routes of administration was almost identical when calculated either by the AUC or the urinary recovery rates.
The in-vitro antibacterial activity of a combination of cefpirome or cefoperazone with vancomycin against enterococci and Staphylococcus aureus.
TLDR
Cefpirome, cefoperazone and ceftazidime were tested for their in-vitro activity against Enterococcus faecalis and methicillin-resistant Staphylococcus aureus isolates and synergy was detected against most MRSA strains and some enterococci.
Mulundocandin, an echinocandin-like lipopeptide antifungal agent: biological activities in vitro.
TLDR
Mulundocandin (MCN) was poorly active against other non-albicans isolates and was inactive against Cryptococcus neoformans, Aspergillus species and Trichophyton.
RU 29 246, the active compound of the cephalosporin-prodrug-ester HR 916. I. Antibacterial activity in vitro.
TLDR
RU 29 246 is a broad spectrum cephalosporin including in its activity both Gram-positive and Gram-negative pathogens and therefore--depending on the bioavailability of its prodrug--looks promising as to its therapeutic perspective.
Bacteremia due to fluoroquinolone-resistantEscherichia coli in two immunocompromised patients
TLDR
Two patients with acute leukemia developedEscherichia coli bacteremia while receiving oral ofloxacin for antibacterial prophylaxis during profound neutropenia, suggesting mutations in the DNA gyrase gene as the significant mechanism of resistance in both strains.
Comparative chemotherapeutic activity of cefpirome and imipenem in experimental infections.
TLDR
Cefpirome was the most active of the three antibiotics in protecting mice challenged with Enterobacteriaceae and was more effective than imipenem and cefotaxime against experimental Klebsiella pneumonia in mice and the Escherichia coli infected granuloma pouch in rats.
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