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Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung.
Pulmonary LCNEC represents an aggressive tumor requiring multimodal treatment even for resectable stage I disease, and LCnEC seems to respond to adjuvant platinum-etoposide-based chemotherapy, and these RTKs seem to be attractive therapeutic targets. Expand
Primary Lung Cancer Presenting with Gastrointestinal Tract Involvement: Clinicopathologic and Immunohistochemical Features in a Series of 18 Consecutive Cases
Although GI metastasis from lung cancer is associated with dismal outcomes, pulmonary resection coupled with chemotherapy might represent a therapeutic option in selected patients with a solitary GI-tract metastasis, pathologists should keep in mind this possibility when dealing with undifferentiated GI carcinoma. Expand
Incidence and causes of non-invasive mechanical ventilation failure after initial success.
The occurrence of "late NIMV failure" was significantly associated with functional limitations (ADL scale) before admission to the respiratory ICU, the presence of medical complications (particularly hyperglycaemia), and a lower pH on admission. Expand
Primary Mucinous (So-called Colloid) Carcinomas of the Lung: A Clinicopathologic and Immunohistochemical Study With Special Reference to CDX-2 Homeobox Gene and MUC2 Expression
MC of the lung represents an entity with two distinct clinicopathologic and immunophenotypic variants: 1) the goblet cell-type, presenting a more indolent clinical behavior and frequently co-expressing markers of intestinal and pulmonary differentiation; and 2) the more aggressive signet-ring cell- type, which retains only markers of pulmonary origin. Expand
PDGFR expression in differential diagnosis between KIT‐negative gastrointestinal stromal tumours and other primary soft‐tissue tumours of the gastrointestinal tract
Aims : To investigate the value of platelet‐derived growth factor receptors (PDGFRs) by immunohistochemistry in discriminating KIT‐negative gastrointestinal stromal tumours (GISTs) from otherExpand
Role of Chemotherapy and the Receptor Tyrosine Kinases KIT, PDGFRα, PDGFRβ, and Met in Large-Cell Neuroendocrine Carcinoma of the Lung
Patients with pure pulmonary LCNEC were reviewed to investigate their clinicopathologic features, therapeutic strategy, and immunohistochemical expression and the mutational status of the receptor tyrosine kinases (RTKs) KIT, PDGFRα,PDGFRβ, and Met. Expand
Kit Expression in Small Cell Carcinomas of the Lung: Effects of Chemotherapy
It is speculated that loss of CD117 expression after chemotherapy in a high proportion of SCLC indicates that in this tumor, Kit unlikely represents the product of a constitutive mutation, as instead shown in gastrointestinal stromal tumors. Expand
Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): study of a comprehensive panel of molecular markers.
The role of EGFR gene mutation is confirmed as predictor of response to EGFR TKIs and, potentially, also EGFR intron 1 polymorphism could aid in better prediction of EG FR TKI responsiveness in advanced NSCLC. Expand
Effectiveness of pulmonary rehabilitation in patients with interstitial lung disease of different etiology: a multicenter prospective study
The present study confirms that comprehensive rehabilitation is feasible and effective in patients with ILD of different severity and etiology and inversely correlates with both functional and symptom gains in this heterogeneous population. Expand
Early Inspiratory Effort Assessment by Esophageal Manometry Predicts Noninvasive Ventilation Outcome in De Novo Respiratory Failure. A Pilot Study
The magnitude of inspiratory effort relief as assessed by ΔPes variation within the first 2 hours of NIV was an early and accurate predictor of N IV outcome at 24 hours. Expand