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Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones.
TLDR
The biological evaluation of reduced analogues and the simulation of the molecular interactions between these compounds and an endogenous cysteine residue suggest that the presence of a non sterically hindered Michael acceptor seems to be an essential structural requirement for the cytoprotective activity in this family of compounds. Expand
Anti-ulcerogenic activity of xanthanolide sesquiterpenes from Xanthium cavanillesii in rats.
TLDR
It is suggested that the mechanism of protection would involve, at least in part, a nucleophylic attack of the sulfhydryl group from the biological molecules present in the gastric mucosa to electrophylic carbons accessible in suitable Michael acceptors. Expand
Diuretic activity of Fabiana patagonica in rats
TLDR
The data reported in the present work indicate that the acetone extract and infusion of the aerial part of Fabiana patagonica showed a moderate diuretic activity, which could be due, in part, to the presence of oleanolic acid isolated as the major metabolite of F. patagonsica. Expand
Evaluation of diuretic activity of the constituents of Clematis montevidensis Spreng. (Ranunculaceae) in rats
TLDR
The data reported in the present work indicate that the infusions of the root and aerial part of Clematis montevidensis showed a moderate diuretic activity, which could be due, at least in part, to the presence of oleanolic acid isolated from this plant. Expand
Gastric cytoprotective activity of dehydroleucodine in rats. Role of nitric oxide.
TLDR
The findings suggest that NO is involved in the gastroprotection induced by DhL, and the gastric cytoprotective effect is antagonized by the nitric oxide synthase inhibitor, NG-nitro-L-arginine. Expand
Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori.
TLDR
Artemisia douglasiana may be a useful alternative treatment strategy principally in eradication of metronidazole and clarithromycin-resistant strain. Expand
Gastric Anti-ulcer Activity of Several α, β-Unsaturated Carbonyl Compounds in Rat
The gastric cytoprotective activity of several molecules containing an α, β-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hinderedExpand
Gastroprotective effects and antimicrobial activity of Lithraea molleoides and isolated compounds against Helicobacter pylori.
TLDR
Findings indicate that L. molleoides displays potential antiulcerogenic and antimicrobial activities and the identification of active principles could support the use of this plant for the treatment of digestive affections. Expand
Cytoprotective effects of chalcones from Zuccagnia punctata and melatonin on the gastroduodenal tract in rats.
TLDR
Both chalcones showed significant preventive effects in treatment with melatonin previous to the necrotising agent, and could be due, in part, to the radical scavenging activity of the melatonin. Expand
Effect of dehydroleucodine in experimental colitis in rats and mice.
TLDR
The results suggest that the protective activity of DhL in experimental colitis is mediated, at least in part, through the increase of glycoprotein synthesis, anti-inflammatory effect and inhibition of COX-2 induction, and by inhibiting the degranulation of cells containing monoamines. Expand
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