The chemokine system in diverse forms of macrophage activation and polarization.
- A. Mantovani, A. Sica, S. Sozzani, P. Allavena, A. Vecchi, M. Locati
- BiologyTrends in immunology
- 1 December 2004
Cancer-related inflammation
- A. Mantovani, P. Allavena, A. Sica, F. Balkwill
- Biology, MedicineNature
- 1 July 2008
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
- A. Mantovani, S. Sozzani, M. Locati, P. Allavena, A. Sica
- BiologyTrends in immunology
- 1 November 2002
Macrophage plasticity and polarization: in vivo veritas.
- A. Sica, A. Mantovani
- BiologyJournal of Clinical Investigation
- 1 March 2012
The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
Macrophage activation and polarization.
- F. MartÃnez, A. Sica, A. Mantovani, M. Locati
- BiologyFrontiers in Bioscience
- 2008
The main functions of polarized macrophages are reviewed and the perspectives of this field are discussed, which include high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-inflammatory cytokine secretion.
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
- S. Biswas, A. Mantovani
- Biology, MedicineNature Immunology
- 1 October 2010
A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.
Inflammation and cancer: back to Virchow?
- F. Balkwill, A. Mantovani
- Biology, MedicineThe Lancet
- 17 February 2001
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1
- F. MartÃnez, S. Gordon, M. Locati, A. Mantovani
- BiologyJournal of Immunology
- 15 November 2006
Transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.
Neutrophils in the activation and regulation of innate and adaptive immunity
- A. Mantovani, M. Cassatella, C. Costantini, S. Jaillon
- Biology, MedicineNature reviews. Immunology
- 1 August 2011
Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has…
...
...