The chemokine system in diverse forms of macrophage activation and polarization.
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
Macrophage plasticity and polarization: in vivo veritas.
The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
Macrophage activation and polarization.
The main functions of polarized macrophages are reviewed and the perspectives of this field are discussed, which include high endocytic clearance capacities and trophic factor synthesis, accompanied by reduced pro-inflammatory cytokine secretion.
Macrophage activation and polarization: nomenclature and experimental guidelines.
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.
Inflammation and cancer: back to Virchow?
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1
Transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.
Neutrophils in the activation and regulation of innate and adaptive immunity
- A. Mantovani, M. Cassatella, C. Costantini, S. Jaillon
- Biology, MedicineNature reviews. Immunology
- 1 August 2011
Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has…