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Amphiphilic Erythromycin-Lipoamino Acid Ion Pairs: Characterization and In Vitro Microbiological Evaluation
An in vitro microbiological assay against different bacterial strains, both susceptible and resistant to macrolides, and the presence of the LAA moiety was shown not altering the antibacterial spectrum of activity of the drug can be the basis for a further evaluation of ERY–LAA ion pairs as a mean to improve the penetration of theDrug inside bacterial cells and to optimize the loading of ERy in lipid-based nanocarriers. Expand
Fosfomycin Tromethamine in Uncomplicated Urinary Tract Infections: an Epidemiological Survey
The aim of the study was to assess the epidemiology of uropathogens isolated from patients who suffered with uncomplicated urinary tract infections to establish guidelines for the empirical treatment of UTIs. Expand
Amphiphilic ion pairs of tobramycin with lipoamino acids.
A series of amphiphilic ion pairs of the aminoglycoside antibiotic tobramycin with lipoamino acids (LAA) bearing an alkyl side chain of 10-14 carbon atoms are described, and the presence of only one LAA moiety did not improve the in vitro antibacterial activity of TOB free base. Expand
Econazole-Polycarbophil, a New Delivery System for Topical Therapy: Microbiological and Clinical Results on Vaginal Candidiasis
It is concluded that, since the women were treated with the same amount of econazole, the better clinical and microbiological results can be attributed to polycarbophil, as confirmed by a significant reduction of recurrences. Expand
In Vitro Evaluation of the Synergistic Activity of Neomycin-Polymyxin B Association against Pathogens Responsible for Otitis Externa
Using a topical formulation containing a synergistic association of antibiotics, such as neomycin-polymyxin B, in such a way as to obtain the maximum effect in the minimum time with an increase in the spectrum of action of non-bacterial pathogens, is an optimal choice for the clinician for the empiric therapy of otitis externa. Expand